Genetic tools for identifying and manipulating fibroblasts in the mouse.
Genetic tools for identifying and manipulating fibroblasts in the mouse.
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DOI：
10.1016/j.diff.2016.05.009
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发表时间：
2016-09
期刊：
影响因子：
2.9
通讯作者：
Tallquist, Michelle D.
中科院分区：
文献类型：
--
作者：
Swonger, Jessica M.;Liu, Jocelyn S.;Ivey, Malina J.;Tallquist, Michelle D.
使用小鼠遗传工具来跟踪和操纵成纤维细胞提供了关于这些细胞的活动的宝贵的体内信息。最近，许多新的小鼠品系已经被描述用于研究成纤维细胞行为的特定目的。表达Cre的比色报告小鼠和细胞系可用于研究易发生纤维化的器官中的成纤维细胞，包括心脏、肾脏、肝脏、肺和骨骼肌。在这篇综述中，我们总结了目前的状态，已被用来定义组织驻留成纤维细胞群体的模型。虽然这些复杂的基因试剂为纤维化过程提供了独特的见解，但它们也需要彻底了解警告和限制。在这里，我们讨论了可用的遗传模型的特异性和效率，并简要描述了它们是如何被用来记录纤维化的机制。
The use of mouse genetic tools to track and manipulate fibroblasts has provided invaluable in vivo information regarding the activities of these cells. Recently, many new mouse strains have been described for the specific purpose of studying fibroblast behavior. Colorimetric reporter mice and lines expressing Cre are available for the study of fibroblasts in the organs prone to fibrosis, including heart, kidney, liver, lung, and skeletal muscle. In this review we summarize the current state of the models that have been used to define tissue resident fibroblast populations. While these complex genetic reagents provide unique insights into the process of fibrosis, they also require a thorough understanding of the caveats and limitations. Here, we discuss the specificity and efficiency of the available genetic models and briefly describe how they have been used to document the mechanisms of fibrosis.
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