Full anatomical recovery of the dopaminergic system after a complete spinal cord injury in lampreys.
Full anatomical recovery of the dopaminergic system after a complete spinal cord injury in lampreys.
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DOI：
10.1155/2015/350750
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发表时间：
2015
影响因子：
3.1
通讯作者：
Rodicio MC
中科院分区：
文献类型：
--
作者：
Fernández-López B;Romaus-Sanjurjo D;Cornide-Petronio ME;Gómez-Fernández S;Barreiro-Iglesias A;Rodicio MC
脊椎损伤后，七鳃鳗首先会在横断水平以下瘫痪。然而，它们在几周后恢复运动，这伴随着大脑中下行轴突的再生和脊髓中新神经元的产生。本研究旨在通过研究脊髓中多巴胺能细胞数和多巴胺能神经支配的变化，来分析完全脊髓横断后七鳃鳗多巴胺能系统的变化。同时观察D2受体表达的变化。我们报告了在多巴胺能细胞和纤维数量最初减少后，多巴胺能系统在解剖上的完全再生。多巴胺能细胞在吻端和尾端恢复到损伤部位。多巴胺能谱定量显示脊髓吻端和尾端的多巴胺能神经支配完全恢复到损伤部位。有趣的是，在观察到脊髓多巴胺能神经支配减少的时间点，D2受体的表达没有变化。我们的观察表明，七鳃鳗脊髓损伤后，多巴胺能系统在解剖上完全恢复。
Following a spinal injury, lampreys at first are paralyzed below the level of transection. However, they recover locomotion after several weeks, and this is accompanied by the regeneration of descending axons from the brain and the production of new neurons in the spinal cord. Here, we aimed to analyse the changes in the dopaminergic system of the sea lamprey after a complete spinal transection by studying the changes in dopaminergic cell numbers and dopaminergic innervation in the spinal cord. Changes in the expression of the D2 receptor were also studied. We report the full anatomical regeneration of the dopaminergic system after an initial decrease in the number of dopaminergic cells and fibres. Numbers of dopaminergic cells were recovered rostrally and caudally to the site of injury. Quantification of dopaminergic profiles revealed the full recovery of the dopaminergic innervation of the spinal cord rostral and caudal to the site of injury. Interestingly, no changes in the expression of the D2 receptor were observed at time points in which a reduced dopaminergic innervation of the spinal cord was observed. Our observations reveal that in lampreys a spinal cord injury is followed by the full anatomical recovery of the dopaminergic system.
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影响因子：
5.3
作者：
Armstrong, J;Zhang, L;McClellan, AD
通讯作者：
McClellan, AD
影响因子：
4.2
作者：
Eugenia Cornide-Petronio, Maria;Soledad Ruiz, Maria;Celina Rodicio, Maria
通讯作者：
Celina Rodicio, Maria
影响因子：
4.2
作者：
Cohen, AH;Abdelnabi, M;Chakrabarti, L
通讯作者：
Chakrabarti, L
影响因子：
2.5
作者：
Kiehn, O;Kjaerulff, O
通讯作者：
Kjaerulff, O
DOI：
10.1007/978-1-4939-0381-8_11
发表时间：
2014-01-01
期刊：
LASER SCANNING MICROSCOPY AND QUANTITATIVE IMAGE ANALYSIS OF NEURONAL TISSUE
影响因子：
--
作者：
Fernandez-Lopez, Blanca;Barreiro-Iglesias, Anton;Celina Rodicio, Maria
通讯作者：
Celina Rodicio, Maria