Trends in incidence and mortality of nasopharyngeal carcinoma over a 20-25 year period (1978/1983-2002) in Sihui and Cangwu counties in southern China.
Trends in incidence and mortality of nasopharyngeal carcinoma over a 20-25 year period (1978/1983-2002) in Sihui and Cangwu counties in southern China.
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DOI：
10.1186/1471-2407-6-178
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发表时间：
2006-07-06
期刊：
影响因子：
3.8
通讯作者：
Zeng YX
中科院分区：
文献类型：
--
作者：
Jia WH;Huang QH;Liao J;Ye W;Shugart YY;Liu Q;Chen LZ;Li YH;Lin X;Wen FL;Adami HO;Zeng Y;Zeng YX
鼻咽癌（NPC）是一种罕见的恶性肿瘤，在世界大部分地区，但在中国南方是常见的。根据华南地区鼻咽癌高发区香港癌症资料统计中心最近的报告显示，在1980至1999年间，鼻咽癌的发病率男性下降了29%，女性下降了30%，而死亡率男性下降了43%，女性下降了50%。环境危险因素的改变和诊治水平的提高是鼻咽癌发病率和死亡率呈下降趋势的主要因素。为了探讨具有不同社会经济背景和生活方式的不同广东人群的长期趋势，我们报告了四会县和苍梧县两个基于人群的癌症登记处1978-2002年的发病率和死亡率。发病率和死亡率按5岁年龄组和5个日历年汇总。为了调整不同时期年龄构成差异的影响，根据世界标准人口（1960年），通过直接标准化调整NPC发病率和死亡率的总比率和年龄别比率。估计年度百分比变化（EAPC）被用作趋势的估计。近20年来四会市和苍梧县女性鼻咽癌发病率基本保持稳定，苍梧县男性鼻咽癌发病率略有上升，从17.81/10万上升到19.76/10万。尽管四会和苍梧都是广东人，但四会的发病率比苍梧高1.4-2.0倍。仅在四会市女性中观察到死亡率逐步下降，每五年平均下降6.3%（p = 0.016）。总之，在中国南方的NPC预防和治疗领域有很大的潜力，以降低NPC的风险和提高生存风险率，以降低M：I比率。本文还讨论了有效预防、早期发现和治疗策略的未来努力。此外，数据的质量和完整性也需要提高。
Nasopharyngeal carcinoma (NPC) is a rare malignancy in most parts of the world but is common in southern China. A recent report from the Hong Kong Cancer Registry, a high-risk area for NPC in southern China, showed that incidence rate decreased by 29% for males and by 30% for females from 1980–1999, while mortality rate decreased by 43% for males and 50% for females. Changing environmental risk factors and improvements in diagnosis and treatment were speculated to be the major factors contributing to the downward trend of the incidence and mortality rates of NPC. To investigate the secular trends in different Cantonese populations with different socio-economic backgrounds and lifestyles, we report the incidences and mortality rates from two population-based cancer registries in Sihui and Cangwu counties from 1978–2002. Incidence and mortality rates were aggregated by 5-year age groups and 5 calendar years. To adjust for the effect of difference in age composition for different periods, the total and age-specific rates of NPC incidence and mortality rate were adjusted by direct standardization according to the World Standard Population (1960). The Estimated Annual Percentage Change (EAPC) was used as an estimate of the trend. The incidence rate of NPC has remained stable during the recent two decades in Sihui and in females in Cangwu, with a slight increase observed in males in Cangwu from 17.81 to 19.76 per 100,000. The incidence rate in Sihui is 1.4–2.0 times higher during the corresponding years than in Cangwu, even though the residents of both areas are of Cantonese ethnicity. A progressive decline in mortality rate was observed in females only in Sihui, with an average reduction of 6.3% (p = 0.016) per five-year period. To summarize, there is great potential to work in the area of NPC prevention and treatment in southern China to decrease NPC risk and improve survival risk rates in order to reduce M:I ratios. Future efforts on effective prevention, early detection and treatment strategies were also discussed in this paper. Furthermore, the data quality and completeness also need to be improved.
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