Diet and gut microbiome enterotype are associated at the population level in African buffalo.
Diet and gut microbiome enterotype are associated at the population level in African buffalo.
复制标题
非洲布法罗群体水平的饮食和肠道微生物组肠型相关。
DOI：
10.1038/s41467-021-22510-8
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发表时间：
2021-04-15
影响因子：
16.6
通讯作者：
Jolles AE
中科院分区：
文献类型：
--
作者：
Couch CE;Stagaman K;Spaan RS;Combrink HJ;Sharpton TJ;Beechler BR;Jolles AE
对人类和实验动物的研究将稳定的肠道微生物组“肠型”与长期饮食和宿主健康联系起来。了解这种范式在野生食草动物中的表现可以为微生物组动态、饮食资源变化和宿主健康结果之间的关系提供机械解释。我们在非洲水牛肠道微生物组中确定了两种假定的肠型。无论环境条件如何，资源丰富的饮食制度下普遍存在的肠型具有高丰富度、低宿主间和宿主内β多样性以及瘤胃球菌属-UCG-005的富集性。第二种肠道型在限制饮食条件下普遍存在，其丰富度降低，β多样性升高，并且 Solibacillus 属丰富。在资源限制期间，通过增加个体之间的β多样性来维持种群水平的伽马多样性，这表明种群水平的微生物组恢复力的机制。我们根据宿主饮食确定了与微生物组变异相关的三种病原体，这表明营养背景可能会影响微生物组-病原体动态。总体而言，这项研究揭示了饮食驱动的肠型可塑性，阐明了维持微生物组多样性的生态过程，并确定了饮食、肠型和疾病之间的潜在关联。人类和实验动物的饮食和微生物组之间存在稳定的关系。一项针对非洲水牛的研究发现，饮食会影响微生物组的变异和肠型的形成。根据宿主饮食，三种病原体可能与微生物组相关，这表明营养会影响肠道微生物组与宿主健康之间的关系。
Studies in humans and laboratory animals link stable gut microbiome “enterotypes” with long-term diet and host health. Understanding how this paradigm manifests in wild herbivores could provide a mechanistic explanation of the relationships between microbiome dynamics, changes in dietary resources, and outcomes for host health. We identify two putative enterotypes in the African buffalo gut microbiome. The enterotype prevalent under resource-abundant dietary regimes, regardless of environmental conditions, has high richness, low between- and within-host beta diversity, and enrichment of genus Ruminococcaceae-UCG-005. The second enterotype, prevalent under restricted dietary conditions, has reduced richness, elevated beta diversity, and enrichment of genus Solibacillus. Population-level gamma diversity is maintained during resource restriction by increased beta diversity between individuals, suggesting a mechanism for population-level microbiome resilience. We identify three pathogens associated with microbiome variation depending on host diet, indicating that nutritional background may impact microbiome-pathogen dynamics. Overall, this study reveals diet-driven enterotype plasticity, illustrates ecological processes that maintain microbiome diversity, and identifies potential associations between diet, enterotype, and disease. There are stable relationships between diet and microbiome in humans and lab animals. A study on African buffalo finds that diet influences microbiome variation and enterotype formation. Three pathogens may associate with microbiome depending on host diet, suggesting nutrition impacts relationships between gut microbiome and host health.
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DOI：
10.1038/nri3535
发表时间：
2013-11
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
通讯作者：
--
影响因子：
48
作者：
Callahan BJ;McMurdie PJ;Rosen MJ;Han AW;Johnson AJ;Holmes SP
通讯作者：
Holmes SP
影响因子：
64.8
作者：
Arumugam, Manimozhiyan;Raes, Jeroen;Pelletier, Eric;Le Paslier, Denis;Yamada, Takuji;Mende, Daniel R.;Fernandes, Gabriel R.;Tap, Julien;Bruls, Thomas;Batto, Jean-Michel;Bertalan, Marcelo;Borruel, Natalia;Casellas, Francesc;Fernandez, Leyden;Gautier, Laurent;Hansen, Torben;Hattori, Masahira;Hayashi, Tetsuya;Kleerebezem, Michiel;Kurokawa, Ken;Leclerc, Marion;Levenez, Florence;Manichanh, Chaysavanh;Nielsen, H. Bjorn;Nielsen, Trine;Pons, Nicolas;Poulain, Julie;Qin, Junjie;Sicheritz-Ponten, Thomas;Tims, Sebastian;Torrents, David;Ugarte, Edgardo;Zoetendal, Erwin G.;Wang, Jun;Guarner, Francisco;Pedersen, Oluf;de Vos, Willem M.;Brunak, Soren;Dore, Joel;Weissenbach, Jean;Ehrlich, S. Dusko;Bork, Peer
通讯作者：
Bork, Peer
影响因子：
1
作者：
Ezenwa, Vanessa O.;Jolles, Anna E.;O'Brien, Michael P.
通讯作者：
O'Brien, Michael P.
影响因子：
--
作者：
Burkepile DE;Parker JD
通讯作者：
Parker JD