Changes in lipid composition associated with electronic cigarette use.
Changes in lipid composition associated with electronic cigarette use.
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DOI：
10.1186/s12967-020-02557-9
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发表时间：
2020-10-07
影响因子：
7.4
通讯作者：
Sallam T
中科院分区：
文献类型：
--
作者：
Middlekauff HR;William KJ;Su B;Haptonstall K;Araujo JA;Wu X;Kim J;Sallam T
尽管有许多报告将电子烟与不良健康结果联系起来，但电子烟的使用仍在增加。最近的研究表明，脂质信号的改变可能是电子烟促进肺功能的机制之一。例如，维生素 E 醋酸盐是通过脂质运输的维生素 E 的合成形式，被发现与电子烟相关的肺损伤有关。脂质对于正常的肺部生理机能绝对至关重要，许多脂质途径的扰动与呼吸系统疾病有关。是否可以想象，即使在看似健康的人群中，电子烟的使用也与脂质途径的改变有关？为了调查与健康人使用电子烟相关的血浆脂质组的定量变化，我们从 119 名男性和女性参与者那里获取了血浆样本，这些参与者是：(1) 长期吸烟 (TC) 吸烟者（自我报告使用 TC 超过 12 个月），(2) 长期使用电子烟 (EC) 使用者（自我报告使用 EC 超过 12 个月），或 (3) 非使用者。我们使用 Sciex Lipidyzer 测量了血浆样本中不同脂质亚类的定量脂质种类。我们发现男性和女性烟草和电子烟使用者在许多脂质种类中具有不同的脂质组特征，尽管与非使用者相比绝大多数脂质没有变化。有趣的是，我们发现女性而非男性电子烟使用者的缩醛磷脂水平较低，缩醛磷脂是肺泡分泌的关键甘油磷脂，是正常表面活性剂功能所需的。总之，我们的研究没有揭示与电子烟使用相关的显着变化，但我们观察到已知对肺功能至关重要的脂质的性别特异性变化。
Electronic cigarette use is on the rise despite a number of reports linking electronic cigarettes with adverse health outcomes. Recent studies have suggested that alterations in lipid signaling may be one mechanism by which electronic cigarettes contribute to lung pulmonary function. Vitamin E acetate, for example, is synthetic form of Vitamin E transported via lipids, found to be associated with electronic cigarette associated lung injury. Lipids are absolutely critical for normal lung physiology and perturbations in a number of lipid pathways have been associated with respiratory illness. Is it conceivable that electronic cigarette use even in seemingly healthy cohorts are associated with alterations in lipid pathways? To investigate quantitative alterations in the plasma lipidome associated with electronic cigarette use in healthy we obtained plasma samples from 119 male and female participants with who were either: (1) chronic tobacco cigarette (TC) smokers (> 12 months of self-reported TC use), (2) chronic Electronic cigarette (EC) users (> 12 months of self-reported EC use), or (3) non-users. We measured quantitative lipid species across different lipid sub-classes from plasma samples using the Sciex Lipidyzer. We found that male and female tobacco and electronic cigarette users had distinct lipidome signatures across a number of lipid species although the vast majority of lipids were unchanged when compared to non-users. Intriguingly, we found that female but not male electronic cigarette users had lower levels of plasmalogens, critical glycerophospholipids secreted by alveoli and required for normal surfactant function. In summary, our study does not reveal striking changes associated with electronic cigarette use but we observed sex-specific changes in lipids known to be critical for lung function.
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影响因子：
9.3
作者：
Middlekauff, Holly R.
通讯作者：
Middlekauff, Holly R.
影响因子：
15.9
作者：
Madison, Matthew C.;Landers, Cameron T.;Kheradmand, Farrah
通讯作者：
Kheradmand, Farrah
影响因子：
158.5
作者：
Hajek, Peter;Phillips-Waller, Anna;McRobbie, Hayden J.
通讯作者：
McRobbie, Hayden J.
影响因子：
14.9
作者：
Metsalu T;Vilo J
通讯作者：
Vilo J
影响因子：
5.2
作者：
Goniewicz ML;Knysak J;Gawron M;Kosmider L;Sobczak A;Kurek J;Prokopowicz A;Jablonska-Czapla M;Rosik-Dulewska C;Havel C;Jacob P 3rd;Benowitz N
通讯作者：
Benowitz N