Seroprevalence of Pertussis in Adults at Childbearing Age Pre- and Post- COVID-19 in Beijing, China.
Seroprevalence of Pertussis in Adults at Childbearing Age Pre- and Post- COVID-19 in Beijing, China.
复制标题
成年人在中国北京的育龄前后成年人的百日咳血清阳性。
DOI：
10.3390/vaccines10060872
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发表时间：
2022-05-29
期刊：
影响因子：
7.8
通讯作者：
He, Qiushui
中科院分区：
文献类型：
--
作者：
Chen, Zhiyun;Pang, Jie;Zhang, Yuxiao;Ding, Yiwei;Chen, Ning;Zhang, Nan;He, Qiushui
在2019年冠状病毒病（COVID-19）大流行期间，受包括中国在内的许多国家采取严格的公共卫生措施的影响，报告的百日咳病例数显着减少。本研究评估了中国北京 COVID-19 前后育龄成人血清抗百日咳毒素 (抗 PT) IgG 抗体的流行情况。对2018~2020年在解放军总医院第六医学中心参加年度健康检查的20~39岁人群采集的2021份血清样本进行ELISA检测。 2020 年参与者中抗 PT IgG 抗体的中位浓度 (2.96 IU/mL) 显着低于 2018 年 (3.27 IU/mL) (p = 0.011) 和 2019 年 (3.24 IU/mL) (p = 0.014)。抗PT IgG抗体高于40 IU/mL（表明过去几年感染过百日咳）的参与者比例在2018年、2019年和2020年分别为1.79%（9/503）、2.04%（15/735）和1.66%（13/783）。对应的抗PT IgG抗体不可检出率(<5 IU/mL)分别为66.60%、65.99%和70.24%。我们的结果表明，即使在 COVID-19 大流行期间，真实发病率和报告发病率之间也存在显着差异。没有百日咳特异性抗体的育龄成年人比例很高，这表明该国应考虑对成年人进行加强疫苗接种。
The number of reported pertussis cases has significantly decreased during the coronavirus disease 2019 (COVID-19) pandemic under the influence of strict public health measures in many countries including China. This study evaluated the prevalence of serum anti-pertussis toxin (anti-PT) IgG antibodies in adults at childbearing age pre- and post- COVID-19 in Beijing, China. Altogether, 2021 serum samples collected from individuals aged 20 to 39 years who attended an annual health examination at the Sixth Medical Center of PLA General Hospital, Beijing, in 2018~2020 were measured by ELISA. The median concentration of anti-PT IgG antibodies among participants in 2020 (2.96 IU/mL) was significantly lower than that in 2018 (3.27 IU/mL) (p = 0.011) and in 2019 (3.24 IU/mL) (p = 0.014). The percentage of participants with anti-PT IgG antibodies higher than 40 IU/mL (indicating a pertussis infection within the past few years) was 1.79% (9/503) in 2018, 2.04% (15/735) in 2019 and 1.66% (13/783) in 2020, respectively. The corresponding numbers of the non-detectable (<5 IU/mL) rate of anti-PT IgG antibodies were 66.60%, 65.99% and 70.24%. Our results showed that there was a significant difference between true and reported incidence rates even during the COVID-19 pandemic. The proportion of adults at childbearing age without pertussis-specific antibodies is high, suggesting that booster vaccinations in adults should be considered in this country.
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