A review of inner ear fate maps and cell lineage studies.
A review of inner ear fate maps and cell lineage studies.
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内耳命运图和细胞谱系研究的回顾。
DOI：
10.1002/neu.10127
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Collazo,Andres
中科院分区：
文献类型：
--
作者：
Kil,Sung-Hee;Collazo,Andres
对内耳发育的重新关注提供了更多关于组成这个复杂结构的组织的命运和细胞谱系关系的数据。内耳从头部的一个简单的外胚层增厚称为耳基板，它经历了大量的生长和分化，形成一个多室的非感觉上皮，容纳内耳的六到九个感觉器官。尽管有大量的研究检查耳部发育，但令人惊讶的是，很少有命运地图。已发表的命运地图包括四个物种，范围从耳前到耳囊阶段。虽然其中一些研究与隔室和边界模型一致，但其他研究显示在发育过程中存在广泛的细胞混合。细胞谱系研究在较少的物种中进行。在单细胞水平上，小鸡和青蛙的克隆似乎在分布上受到一定的限制。我们的结论是，直到基板晚期阶段，没有明确的谱系限制边界，这意味着细胞似乎在这些早期阶段广泛混合。在基板晚期，当耳杯形成时，形成的耳囊中至少有两个边界位于背侧，但腹侧没有。这些结论与所有的命运图一致，并与鸡和青蛙的数据一致。这些结果表明，参与内耳模式的基因可能具有动态和复杂的表达模式。© 2002 Wiley Periodicals，Inc. J Neurobiol 53：129-142，2002
A renewed interest in the development of the inner ear has provided more data on the fate and cell lineage relationships of the tissues making up this complex structure. The inner ear develops from a simple ectodermal thickening of the head called the otic placode, which undergoes a great deal of growth and differentiation to form a multichambered nonsensory epithelium that houses the six to nine sensory organs of the inner ear. Despite a large number of studies examining otic development, there have been surprisingly few fate maps generated. The published fate maps encompass four species and range from preotic to otocyst stages. Although some of these studies were consistent with a compartment and boundary model, other studies reveal extensive cell mixing during development. Cell lineage studies have been done in fewer species. At the single cell level the resulting clones in both chicks and frogs appear somewhat restricted in terms of distribution. We conclude that up until late placode stages there are no clear lineage restriction boundaries, meaning that cells seem to mix extensively at these early stages. At late placode stages, when the otic cup has formed, there are at least two boundaries located dorsally in the forming otocyst but none ventrally. These conclusions are consistent with all the fate maps and reconciles the chick and frog data. These results suggest that genes involved in patterning the inner ear may have dynamic and complex expression patterns. © 2002 Wiley Periodicals, Inc. J Neurobiol 53: 129–142, 2002
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