The effects of genetic polymorphisms of APOE on circulating lipid levels in middle-aged and elderly chinese Fujian Han population: toward age- and sex-personalized management.
The effects of genetic polymorphisms of APOE on circulating lipid levels in middle-aged and elderly chinese Fujian Han population: toward age- and sex-personalized management.
复制标题
APOE基因多态性对福建汉族中老年人循环血脂水平的影响：面向年龄和性别的个性化管理
DOI：
10.1186/s12944-021-01587-6
复制
发表时间：
2021-11-08
影响因子：
4.5
通讯作者：
Ou Q
中科院分区：
文献类型：
--
作者：
Liu X;Lin Q;Fan K;Tang M;Zhang W;Yang B;Ou Q
背景
越来越多的证据表明载脂蛋白E（APOE）基因多态性与血脂相关。然而，很少有研究探讨APOE，性别和年龄的综合影响。
方法
共随机抽取1,419名中老年受试者进行研究。检测载脂蛋白E基因型及血脂水平。初步观察了APOE、性别、年龄对血脂的影响。然后将受试者分为中年组（40-64岁）和老年组（≥ 65岁），男性和女性，以探讨APOE、性别和年龄对血脂的综合影响。最后，采用多因素logistic回归模型评估APOE等位基因携带者与血脂异常风险水平之间的关系。
结果
ε2携带者的血清TC、LDL-C和ApoB低于ε3携带者（均P 0.05），ε4携带者与ε3携带者相比总体上无显著差异（均P 0.05）。中老年男性ε2携带者血清LDL-C、ApoB水平低于非携带者（均P0.05）。ε2携带者血清TC仅在中年男性低于非携带者（P0.05）。中年女性ε2携带者血清HDL-C、ApoA 1水平高于非携带者（均P0.05），中年男性ε4携带者血清HDL-C、ApoA 1水平低于非携带者（均P0.05）。尤其是老年女性ε4携带者血清TG水平明显高于非携带者。Logistic回归分析表明，ε2携带者在中年和老年男性中不太可能具有高LDL-C的风险水平（均P 0.05），而在中年女性中则不太可能具有低HDL-C的风险水平（P 0.05）。相比之下，老年女性中ε4携带者更有可能出现高TG风险水平（P 0.05）。
结论
APOE基因多态性对福建汉族中老年人群血脂水平的影响具有性别和年龄依赖性。
Background
Increased evidence has reported the association of genetic polymorphisms of Apolipoprotein E (APOE) with serum lipids. However, few studies have explored the combined effects of APOE, gender, and age.
Methods
A total of 1,419 middle-aged and elderly subjects were randomly selected and studied. The APOE genotypes and the serum lipids were detected. The effects of APOE, gender, and age on serum lipids were preliminarily observed in general. The subjects were then divided into the middle-aged group (40–64 years old) and the elderly group (≥ 65 years old), for both males and females, to explore the combined effects of the APOE, gender, and age on serum lipids. Finally, a multivariate logistic regression model was used to evaluate the associations between the APOE allele carriers and the at-risk levels of dyslipidemia.
Results
The serum TC, LDL-C, and ApoB in the ε2 carriers were lower than the ε3 carriers (all P 0.05), and there was no significant difference in the ε4 carriers compared to the ε3 carriers in general (all P 0.05). The serum LDL-C and ApoB of the ε2 carriers were lower than the noncarriers in the middle-aged and elderly males (all P 0.05). The serum TC in the ε2 carriers was lower than the noncarriers only in middle-aged males (P 0.05). As to the levels of serum HDL-C and ApoA1, the ε2 carriers were higher than the noncarriers in middle-aged females (all P 0.05), and the ε4 carriers were lower than noncarriers in middle-aged males (P 0.05). Especially, the serum TG in the ε4 carriers was significantly higher than the noncarriers in elderly females. The logistic regression analysis indicated that the ε2 carriers were less likely to have at-risk levels of high LDL-C in middle-aged and elderly males (all P 0.05) versus low HDL-C in middle-aged females (P 0.05). In contrast, the ε4 carriers were more likely to have at-risk levels of high TG in elderly females (P 0.05).
Conclusions
The effects of the genetic polymorphisms of APOE on the serum lipids were both gender- and age-dependent in the middle-aged and elderly Chinese Fujian Han population.
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作者：
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