Systemic, Mucosal, and Memory Immune Responses following Cholera.
Systemic, Mucosal, and Memory Immune Responses following Cholera.
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DOI：
10.3390/tropicalmed6040192
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发表时间：
2021-10-27
影响因子：
2.9
通讯作者：
Charles RC
中科院分区：
文献类型：
--
作者：
Ryan ET;Leung DT;Jensen O;Weil AA;Bhuiyan TR;Khan AI;Chowdhury F;LaRocque RC;Harris JB;Calderwood SB;Qadri F;Charles RC
霍乱弧菌 O1 是霍乱的主要病原体，仍然对公共卫生构成重大威胁。尽管已有霍乱疫苗，但灭活全细胞霍乱疫苗对幼儿提供的保护作用很差。开发改进的霍乱疫苗的一个障碍是需要更好地了解霍乱免疫的主要机制并确定改进的保护相关性。过去十年来，在了解霍乱疾病以及霍乱弧菌感染的适应性和先天免疫反应方面已经取得了相当大的进展。本综述将评估目前对临床霍乱的全身、粘膜、记忆和先天免疫反应的了解，以及我们对霍乱弧菌 O1 感染保护机制和相关性的理解的最新进展。
Vibrio cholerae O1, the major causative agent of cholera, remains a significant public health threat. Although there are available vaccines for cholera, the protection provided by killed whole-cell cholera vaccines in young children is poor. An obstacle to the development of improved cholera vaccines is the need for a better understanding of the primary mechanisms of cholera immunity and identification of improved correlates of protection. Considerable progress has been made over the last decade in understanding the adaptive and innate immune responses to cholera disease as well as V. cholerae infection. This review will assess what is currently known about the systemic, mucosal, memory, and innate immune responses to clinical cholera, as well as recent advances in our understanding of the mechanisms and correlates of protection against V. cholerae O1 infection.
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影响因子：
3.1
作者：
Bourque, Daniel L.;Bhuiyan, Taufiqur Rahman;Harris, Jason B.
通讯作者：
Harris, Jason B.
影响因子：
3.8
作者：
Adekunle O;Dretler A;Kauffman RC;Cho A;Rouphael N;Wrammert J
通讯作者：
Wrammert J
影响因子：
--
作者：
Aktar, Amena;Rahman, M. Arifur;Ryan, Edward T.
通讯作者：
Ryan, Edward T.
影响因子：
6.4
作者：
CLEMENTS, ML;LEVINE, MM;CRAIG, JP
通讯作者：
CRAIG, JP
影响因子：
6.4
作者：
Charles, Richelle C.;Nakajima, Rie;Ryan, Edward T.
通讯作者：
Ryan, Edward T.