Applying Compressed Sensing Volumetric Interpolated Breath-Hold Examination and Spiral Ultrashort Echo Time Sequences for Lung Nodule Detection in MRI.
Applying Compressed Sensing Volumetric Interpolated Breath-Hold Examination and Spiral Ultrashort Echo Time Sequences for Lung Nodule Detection in MRI.
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DOI：
10.3390/diagnostics12010093
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发表时间：
2021-12-31
期刊：
影响因子：
--
通讯作者：
Chang YC
中科院分区：
文献类型：
--
作者：
Huang YS;Niisato E;Su MM;Benkert T;Chien N;Chiang PY;Lee WJ;Chen JS;Chang YC
本前瞻性研究旨在探讨螺旋超短回波时间（UTE）和压缩感知容积内插屏气检查（CS-VIBE）序列在磁共振成像（MRI）中的成像质量和小结节检测能力，并与传统VIBE和胸部计算机断层扫描（CT）进行比较。前瞻性纳入了计划行视频胸腔镜手术（VATS）肺楔形切除术的小肺结节患者。每位患者在胸外科手术前的同一天接受了胸部CT和MRI检查。进行胸部CT以获得结节大小、位置和形态的标准参考。胸部MRI包括屏气常规VIBE和CS-VIBE，扫描时间分别为11 s和13 s，自由呼吸螺旋UTE扫描时间为3.5-5 min。通过测量信噪比（SNR）、噪声对比比（CNR）和正常结构可视化来评估MRI质量。结节检测灵敏度按叶对叶进行评估。使用Cohen κ统计量进行阅读器间和模态间信度分析，使用Bland-Altman图进行结节大小比较。96例需要手术的肺结节中，平均结节直径为7.7±3.9 mm（范围：4 ~ 20 mm）；在切除的73个结节中，大多数是浸润性癌（74%）或浸润前原位癌（15%）。与传统的VIBE相比，螺旋UTE和CS-VIBE图像的整体图像质量得分、信噪比和信噪比都明显更高。螺旋UTE（81%）和CS-VIBE（83%）的肺结节检出率高于常规VIBE（53%）。其中螺旋UTE和CS-VIBE对bbb8和>0 mm的结节检出率分别达到95%和100%。对于部分固体或固体形态的各种大小的结节，检出率达到90%。与参考CT相比，螺旋UTE和CS-VIBE分别低估了结节大小0.2±1.4 mm和0.2±1.7 mm， 95%的一致性范围为−2.6至2.9 mm， 95%的一致性范围为−3.3至3.5 mm。综上所述，胸部CT具有较高的图像分辨率，仍然是肺结节检测的金标准。螺旋UTE和CS-VIBE MRI都可以发现需要手术的小肺结节，可以被认为是胸部CT的潜在替代方案；但其临床应用还需进一步研究。
This prospective study aimed to investigate the ability of spiral ultrashort echo time (UTE) and compressed sensing volumetric interpolated breath-hold examination (CS-VIBE) sequences in magnetic resonance imaging (MRI) compared to conventional VIBE and chest computed tomography (CT) in terms of image quality and small nodule detection. Patients with small lung nodules scheduled for video-assisted thoracoscopic surgery (VATS) for lung wedge resection were prospectively enrolled. Each patient underwent non-contrast chest CT and non-contrast MRI on the same day prior to thoracic surgery. The chest CT was performed to obtain a standard reference for nodule size, location, and morphology. The chest MRI included breath-hold conventional VIBE and CS-VIBE with scanning durations of 11 and 13 s, respectively, and free-breathing spiral UTE for 3.5–5 min. The signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), and normal structure visualizations were measured to evaluate MRI quality. Nodule detection sensitivity was evaluated on a lobe-by-lobe basis. Inter-reader and inter-modality reliability analyses were performed using the Cohen κ statistic and the nodule size comparison was performed using Bland–Altman plots. Among 96 pulmonary nodules requiring surgery, the average nodule diameter was 7.7 ± 3.9 mm (range: 4–20 mm); of the 73 resected nodules, most were invasive cancer (74%) or pre-invasive carcinoma in situ (15%). Both spiral UTE and CS-VIBE images achieved significantly higher overall image quality scores, SNRs, and CNRs than conventional VIBE. Spiral UTE (81%) and CS-VIBE (83%) achieved a higher lung nodule detection rate than conventional VIBE (53%). Specifically, the nodule detection rate for spiral UTE and CS-VIBE reached 95% and 100% for nodules >8 and >10 mm, respectively. A 90% detection rate was achieved for nodules of all sizes with a part-solid or solid morphology. Spiral UTE and CS-VIBE under-estimated the nodule size by 0.2 ± 1.4 mm with 95% limits of agreement from −2.6 to 2.9 mm and by 0.2 ± 1.7 mm with 95% limits of agreement from −3.3 to 3.5 mm, respectively, compared to the reference CT. In conclusion, chest CT remains the gold standard for lung nodule detection due to its high image resolutions. Both spiral UTE and CS-VIBE MRI could detect small lung nodules requiring surgery and could be considered a potential alternative to chest CT; however, their clinical application requires further investigation.
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影响因子：
3.3
作者：
Feng, Li;Grimm, Robert;Block, Kai Tobias;Chandarana, Hersh;Kim, Sungheon;Xu, Jian;Axel, Leon;Sodickson, Daniel K.;Otazo, Ricardo
通讯作者：
Otazo, Ricardo
DOI：
10.1007/s10334-020-00885-x
发表时间：
2020-09-09
影响因子：
2.3
作者：
Huang, Yu-Sen;Niisato, Emi;Chang, Yeun-Chung
通讯作者：
Chang, Yeun-Chung
影响因子：
19.7
作者：
Dournes, Gael;Grodzki, David;Laurent, Francois
通讯作者：
Laurent, Francois
影响因子：
2.5
作者：
Cha, Min Jae;Park, Hyun Jeong;Kim, Yang Soo
通讯作者：
Kim, Yang Soo
影响因子：
9.6
作者：
Libby, DM;Smith, JP;Henschke, CI
通讯作者：
Henschke, CI