SATB2: A versatile transcriptional regulator of craniofacial and skeleton development, neurogenesis and tumorigenesis, and its applications in regenerative medicine.
SATB2: A versatile transcriptional regulator of craniofacial and skeleton development, neurogenesis and tumorigenesis, and its applications in regenerative medicine.
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SATB2：颅面和骨骼发育、神经发生和肿瘤发生的多功能转录调节因子及其在再生医学中的应用
DOI：
10.1016/j.gendis.2020.10.003
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发表时间：
2022-01
期刊：
影响因子：
6.8
通讯作者：
Zhang H
中科院分区：
文献类型：
--
作者：
Huang X;Chen Q;Luo W;Pakvasa M;Zhang Y;Zheng L;Li S;Yang Z;Zeng H;Liang F;Zhang F;Hu DA;Qin KH;Wang EJ;Qin DS;Reid RR;He TC;Athiviraham A;El Dafrawy M;Zhang H
SATB2 （special AT-rich sequence-binding protein 2）是特殊AT-rich binding protein家族的成员。作为转录调控因子，SATB2主要整合高阶染色质组织。SATB2的表达似乎是组织和阶段特异性的，并受几种细胞信号分子和介质的控制。在鳃弓和成骨细胞谱系中表达，SATB2在颅面形态和骨骼发育中起重要作用。除了调节成骨分化外，SATB2在神经发育和癌症进展中也显示出多种功能。SATB2作为一种骨诱导因子，在促进骨再生、修复骨缺损方面具有很大的应用前景。本文就SATB2在颅面和骨骼发育、神经发生、肿瘤发生和再生医学等方面的生理病理功能作一综述。
SATB2 (special AT-rich sequence-binding protein 2) is a member of the special AT-rich binding protein family. As a transcription regulator, SATB2 mainly integrates higher-order chromatin organization. SATB2 expression appears to be tissue- and stage-specific, and is governed by several cellular signaling molecules and mediators. Expressed in branchial arches and osteoblast-lineage cells, SATB2 plays a significant role in craniofacial pattern and skeleton development. In addition to regulating osteogenic differentiation, SATB2 also displays versatile functions in neural development and cancer progression. As an osteoinductive factor, SATB2 holds great promise in improving bone regeneration toward bone defect repair. In this review, we have summarized our current understanding of the physiological and pathological functions of SATB2 in craniofacial and skeleton development, neurogenesis, tumorigenesis and regenerative medicine.
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DOI：
10.1038/nrc.2017.99
发表时间：
2018-01
期刊：
Nature reviews. Cancer
影响因子：
--
作者：
Anastasiadou E;Jacob LS;Slack FJ
通讯作者：
Slack FJ
影响因子：
3.1
作者：
Yan SG;Zhang J;Tu Q;Ye JH;Luo E;Schuler M;Dard MM;Yu Y;Murray D;Cochran DL;Kim SH;Yang P;Chen J
通讯作者：
Chen J
影响因子：
19
作者：
Bronner-Fraser, Marianne
通讯作者：
Bronner-Fraser, Marianne
影响因子：
4.8
作者：
Caperuto, Luciana Chagas;Anhe, Gabriel Forato;Bordin, Silvana
通讯作者：
Bordin, Silvana
影响因子：
16.2
作者：
Alcamo, Elizabeth A.;Chirivella, Laura;McConnell, Susan K.
通讯作者：
McConnell, Susan K.