Clinical characteristics and mortality associated with COVID-19 in Jakarta, Indonesia: A hospital-based retrospective cohort study.
Clinical characteristics and mortality associated with COVID-19 in Jakarta, Indonesia: A hospital-based retrospective cohort study.
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DOI：
10.1016/j.lanwpc.2021.100108
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发表时间：
2021-04
期刊：
影响因子：
--
通讯作者：
Hamers RL
中科院分区：
文献类型：
--
作者：
Surendra H;Elyazar IR;Djaafara BA;Ekawati LL;Saraswati K;Adrian V;Widyastuti;Oktavia D;Salama N;Lina RN;Andrianto A;Lestari KD;Burhan E;Shankar AH;Thwaites G;Baird JK;Hamers RL
有关低资源环境中COVID-19相关死亡率和相关因素的数据很少。这项研究检查了2020年3月2日至7月31日期间印度尼西亚雅加达COVID-19患者的临床特征和住院死亡率相关因素。该回顾性队列包括55家医院的所有PCR确诊的COVID-19住院患者。我们提取了人口统计学和临床数据，包括医院结局（出院或死亡）。我们使用逻辑回归分析与死亡率相关的因素。截至7月31日，在4265例具有明确结局的患者中，3768例（88%）出院，497例（12%）死亡。中位年龄为46岁（IQR 32-57），5%为儿童，31%有>1种合并症。<5岁的特定年龄死亡率为11%（7/61）; 5-9岁为4%（1/23）; 10-19岁为2%（3/133）; 20-29岁为2%（8/638）; 30-39岁为3%（26/755）; 40-49岁为7%（61/819）; 50- 5 - 9岁为17%（155/941）; 60-69岁为22%（132/611）; ≥70岁为34%（96/284）。死亡风险与较高年龄、男性、既往高血压、糖尿病或慢性肾脏疾病、临床诊断为肺炎、多种（>3种）症状、立即入住ICU或插管相关。在所有年龄段中，合并症>1例的患者死亡风险高于无合并症的患者;值得注意的是，<50岁的患者死亡风险增加了6倍（校正优势比5.87，95%CI 3.28-10.52;死亡率27% vs 3%）。总体住院死亡率低于高收入国家的报告，可能是由于年龄分布较年轻和合并症较少。死亡发生在所有年龄段，50岁儿童死亡率>10%<5 years and adults >。Wellcome Trust UK.
Data on COVID-19-related mortality and associated factors from low-resource settings are scarce. This study examined clinical characteristics and factors associated with in-hospital mortality of COVID-19 patients in Jakarta, Indonesia, from March 2 to July 31, 2020. This retrospective cohort included all hospitalised patients with PCR-confirmed COVID-19 in 55 hospitals. We extracted demographic and clinical data, including hospital outcomes (discharge or death). We used logistic regression to examine factors associated with mortality. Of 4265 patients with a definitive outcome by July 31, 3768 (88%) were discharged and 497 (12%) died. The median age was 46 years (IQR 32–57), 5% were children, and 31% had >1 comorbidity. Age-specific mortalities were 11% (7/61) for <5 years; 4% (1/23) for 5–9; 2% (3/133) for 10–19; 2% (8/638) for 20–29; 3% (26/755) for 30–39; 7% (61/819) for 40–49; 17% (155/941) for 50–59; 22% (132/611) for 60–69; and 34% (96/284) for ≥70. Risk of death was associated with higher age, male sex; pre-existing hypertension, diabetes, or chronic kidney disease; clinical diagnosis of pneumonia; multiple (>3) symptoms; immediate ICU admission, or intubation. Across all ages, risk of death was higher for patients with >1 comorbidity compared to those without; notably the risk was six-fold increased among patients <50 years (adjusted odds ratio 5.87, 95%CI 3.28–10.52; 27% vs 3% mortality). Overall in-hospital mortality was lower than reported in high-income countries, probably due to younger age distribution and fewer comorbidities. Deaths occurred across all ages, with >10% mortality among children <5 years and adults >50 years. Wellcome Trust UK.
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影响因子：
4.2
作者：
Santos, M. M.;Lucena, E. E. S.;Bonfada, D.
通讯作者：
Bonfada, D.
影响因子：
4.8
作者：
Tan KK;Dang DA;Kim KH;Kartasasmita C;Kim HM;Zhang XH;Shafi F;Yu TW;Ledesma E;Meyer N
通讯作者：
Meyer N
DOI：
10.1073/pnas.2012358117
发表时间：
2020-10-06
影响因子：
11.1
作者：
Steinman JB;Lum FM;Ho PP;Kaminski N;Steinman L
通讯作者：
Steinman L
影响因子：
8.4
作者：
Azmi, Soraya;Aljunid, Syed Mohamed;Roberts, Craig
通讯作者：
Roberts, Craig
DOI：
10.1016/s0140-6736(18)30595-6
发表时间：
2018-08-18
期刊：
Lancet (London, England)
影响因子：
--
作者：
Mboi N;Murty Surbakti I;Trihandini I;Elyazar I;Houston Smith K;Bahjuri Ali P;Kosen S;Flemons K;Ray SE;Cao J;Glenn SD;Miller-Petrie MK;Mooney MD;Ried JL;Nur Anggraini Ningrum D;Idris F;Siregar KN;Harimurti P;Bernstein RS;Pangestu T;Sidharta Y;Naghavi M;Murray CJL;Hay SI
通讯作者：
Hay SI