Reduced development of COVID-19 in children reveals molecular checkpoints gating pathogenesis illuminating potential therapeutics.
Reduced development of COVID-19 in children reveals molecular checkpoints gating pathogenesis illuminating potential therapeutics.
复制标题
DOI：
10.1073/pnas.2012358117
复制
发表时间：
2020-10-06
影响因子：
11.1
通讯作者：
Steinman L
中科院分区：
文献类型：
--
作者：
Steinman JB;Lum FM;Ho PP;Kaminski N;Steinman L
与成人相比，儿童COVID-19的发展速度较低，这为这一大流行性病毒的发病机制和传播性提供了一些诱人的线索。首先，ACE 2，严重急性呼吸综合征冠状病毒2（SARS-CoV-2）受体，在儿童呼吸道中减少。其次，由于普通冠状病毒和SARS-CoV-2之间的交叉反应性体液免疫和T细胞免疫，与儿童普通感冒相关的冠状病毒可能提供一些保护。第三，辅助性T细胞2免疫应答在儿童中具有保护作用。第四，令人惊讶的是，与辅助性T细胞2相关的嗜酸性粒细胞增多症可能具有保护作用。第五，儿童通常产生较低水平的炎性细胞因子。最后，还考虑了全球经济衰退的影响、住在风险最大的家庭宿舍的影响以及一些学校开学等因素。那些在社会经济上处于最不利地位的人可能会因COVID-19而受到不成比例的影响。
The reduced development of COVID-19 for children compared to adults provides some tantalizing clues on the pathogenesis and transmissibility of this pandemic virus. First, ACE2, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor, is reduced in the respiratory tract in children. Second, coronavirus associated with common colds in children may offer some protection, due to cross-reactive humoral immunity and T cell immunity between common coronaviruses and SARS-CoV-2. Third, T helper 2 immune responses are protective in children. Fourth, surprisingly, eosinophilia, associated with T helper 2, may be protective. Fifth, children generally produce lower levels of inflammatory cytokines. Finally, the influence of the downturn in the global economy, the impact of living in quarters among families who are the most at risk, and factors including the openings of some schools, are considered. Those most disadvantaged socioeconomically may suffer disproportionately with COVID-19.
登录
查看更多内容
DOI：
10.15585/mmwr.mm6915e3
发表时间：
2020-04-17
期刊：
MMWR. Morbidity and mortality weekly report
影响因子：
--
作者：
Garg S;Kim L;Whitaker M;O'Halloran A;Cummings C;Holstein R;Prill M;Chai SJ;Kirley PD;Alden NB;Kawasaki B;Yousey-Hindes K;Niccolai L;Anderson EJ;Openo KP;Weigel A;Monroe ML;Ryan P;Henderson J;Kim S;Como-Sabetti K;Lynfield R;Sosin D;Torres S;Muse A;Bennett NM;Billing L;Sutton M;West N;Schaffner W;Talbot HK;Aquino C;George A;Budd A;Brammer L;Langley G;Hall AJ;Fry A
通讯作者：
Fry A
影响因子：
2.6
作者：
Decker, Marie-Luise;Grobusch, Martin P.;Ritz, Nicole
通讯作者：
Ritz, Nicole
DOI：
10.1164/rccm.202003-0543oc
发表时间：
2020-06-01
影响因子：
24.7
作者：
Du, Yingzhen;Tu, Lei;Xu, Guogang
通讯作者：
Xu, Guogang
DOI：
10.1007/978-1-4939-2438-7_1
发表时间：
2015
期刊：
Methods in molecular biology (Clifton, N.J.)
影响因子：
--
作者：
Fehr, Anthony R;Perlman, Stanley
通讯作者：
Perlman, Stanley
影响因子：
--
作者：
Jones, Veena G;Mills, Marcos;Mathew, Roshni
通讯作者：
Mathew, Roshni