The Antidepressant Effect of Angelica sinensis Extracts on Chronic Unpredictable Mild Stress-Induced Depression Is Mediated via the Upregulation of the BDNF Signaling Pathway in Rats.
The Antidepressant Effect of Angelica sinensis Extracts on Chronic Unpredictable Mild Stress-Induced Depression Is Mediated via the Upregulation of the BDNF Signaling Pathway in Rats.
复制标题
当归提取物对大鼠慢性不可预测的轻度应激性抑郁症的抗抑郁作用是通过上调 BDNF 信号通路介导的
DOI：
10.1155/2016/7434692
复制
发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Zhang L
中科院分区：
文献类型：
--
作者：
Shen J;Zhang J;Deng M;Liu Y;Hu Y;Zhang L
当归（Angelica sinensis，AS）是一种传统的中草药，具有治疗月经失调、心脑血管疾病、认知障碍等方面的药理作用。然而，直到最近，很少有研究探讨其抗抑郁作用。本研究旨在探讨黄芪提取物对慢性不可预见性轻度应激（C应激）诱导的大鼠抑郁的影响。雄性SD大鼠经5周的诱导程序诱导产生抑郁行为，表现为蔗糖偏好实验中蔗糖消耗量减少、蔗糖偏好比降低，强迫游泳实验中不动时间延长、挣扎时间减少，旷场实验中自发活动减少。此外，抑郁大鼠海马区脑源性神经营养因子（BDNF）的表达、cAMP反应元件结合蛋白（CREB）和细胞外信号调节蛋白激酶（ERK 1/2）的磷酸化水平均明显降低。然而，慢性治疗抑郁大鼠与AS（1 g/kg）正常化其抑郁相关的行为和分子谱。总之，在本研究中，我们表明，AS提取物产生的抗抑郁作用，介导的BDNF信号通路：在AS治疗抑郁症大鼠，BDNF蛋白的表达和磷酸化的下游目标（ERK 1/2，CREB）上调海马。
Angelica sinensis (AS), a traditional Chinese herbal medicine, has pharmaceutical effects on menstrual illness, cerebrovascular diseases, cardiovascular diseases, and cognitive impairments. However, until recently, few studies had explored its antidepressant effect. The current study attempts to investigate the effect of AS extracts on chronic unpredictable mild stress- (CUMS-) induced depression in rats. Male SD rats were exposed to a CUMS-inducing procedure for 5 weeks, resulting in rodent depressive behaviors that included reduced sucrose consumption and lessened sucrose preference ratios in sucrose preference test, prolonged immobility times and decreased struggling time in force swim test, and decreased locomotor activity in open field test. Moreover, the expression of brain derived neurotrophic factor (BDNF) and the phosphorylation of cAMP-response element binding protein (CREB) and extracellular signal-regulated protein kinase (ERK 1/2) were markedly decreased in the hippocampus in depressed rats. However, chronically treating the depressed rats with AS (1 g/kg) normalized their depression-related behaviors and molecular profiles. In conclusion, in the present study, we show that AS extracts exerted antidepressant effects that were mediated by the BDNF signaling pathway: in AS-treated depressed rats, the expression of the BDNF protein and the phosphorylation of its downstream targets (ERK 1/2, CREB) were upregulated in the hippocampus.
登录
查看更多内容
关于中草药配方的Danggui-shaoyao-san抗抑郁样作用的机械研究。
DOI：
10.1155/2012/173565
发表时间：
2012
期刊：
Evidence-based complementary and alternative medicine : eCAM
影响因子：
--
作者：
Huang Z;Mao QQ;Zhong XM;Li ZY;Qiu FM;Ip SP
通讯作者：
Ip SP
影响因子：
2.7
作者：
Hurley, Laura L.;Akinfiresoye, Luli;Nwulia, Evaristus;Kamiya, Atsushi;Kulkarni, Amol A.;Tizabi, Yousef
通讯作者：
Tizabi, Yousef
影响因子：
2.7
作者：
Koike, Hiroyuki;Fukumoto, Kenichi;Chaki, Shigeyuki
通讯作者：
Chaki, Shigeyuki
影响因子：
10.6
作者：
Sen, Srijan;Duman, Ronald;Sanacora, Gerard
通讯作者：
Sanacora, Gerard
运动可改善卵巢切除大鼠的抑郁样行为并增加海马 BDNF 水平
影响因子：
2.5
作者：
Lu, Jianqiang;Xu, Yongjun;Liu, Yu
通讯作者：
Liu, Yu