Antidepressant-like effects of curcumin in WKY rat model of depression is associated with an increase in hippocampal BDNF.
Antidepressant-like effects of curcumin in WKY rat model of depression is associated with an increase in hippocampal BDNF.
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DOI：
10.1016/j.bbr.2012.10.049
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发表时间：
2013-02-15
影响因子：
2.7
通讯作者：
Tizabi, Yousef
中科院分区：
文献类型：
--
作者：
Hurley, Laura L.;Akinfiresoye, Luli;Nwulia, Evaristus;Kamiya, Atsushi;Kulkarni, Amol A.;Tizabi, Yousef
姜黄素是姜黄（Curcuma longa）中发现的主要活性成分，姜黄是一种用于传统亚洲饮食和草药的植物。已知它具有广泛的生物学作用，包括在应激诱导的抑郁模型中观察到的抗抑郁样作用。本研究旨在探讨姜黄素在非诱导抑郁模型中的抗抑郁潜力。此外，由于脑源性神经营养因子（BDNF）已被牵连在许多药物的抗抑郁作用，我们还评估了姜黄素对海马BDNF的影响。成年雄性Wistar京都（WKY）大鼠，一个假定的抑郁症模型，急性或慢性（10天）注射50，100，和200 mg/kg姜黄素。在急性注射后1小时和最后一次慢性注射后18-20小时测量旷场运动活动（OFLA）和强迫游泳试验（FST）（无助的量度）。结果显示，在急性和慢性研究中，姜黄素均能剂量依赖性地降低FST中的不动性，对OFLA无任何显著影响。一周后，较高的慢性姜黄素剂量在FST中的作用仍然明显。慢性姜黄素也导致海马BDNF的剂量依赖性增加。该数据提供了姜黄素在WKY抑郁症模型中可能通过增加神经营养活性而具有抗抑郁样作用的证据，并支持姜黄素可能被证明是一种有效且持久的天然抗抑郁药的观点。
Curcumin is the principal active ingredient found in turmeric (Curcuma longa), a plant used in traditional Asian diets and herbal medicines. It is known to have a wide range of biological actions including antidepressant-like effects which have been observed in stress-induced depression models. This study was designed to investigate the antidepressant potential of curcumin in a non-induced model of depression. Moreover, since brain derived neurotrophic factor (BDNF) has been implicated in antidepressant effects of many drugs, we also evaluated the effects of curcumin on BDNF in the hippocampus. Adult male Wistar Kyoto (WKY) rats, a putative model of depression, were injected acutely or chronically (10 d) with 50, 100, and 200mg/kg curcumin. Open field locomotor activity (OFLA) and forced swim test (FST), a measure of helplessness, were measured 1 hour after acute and 18–20 hours after last chronic injection. Results showed a dose-dependent reduction of immobility in the FST by curcumin in both acute and chronic studies, without any significant effect on OFLA. The effect of higher chronic curcumin dose in FST was still evident a week later. Chronic curcumin also resulted in a dose-dependent increase in hippocampal BDNF. This data provides evidence for an antidepressant-like effect of curcumin, possibly through increased neurotrophic activity, in the WKY model of depression, and support the notion that curcumin may prove an effective and lasting natural antidepressant.
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