Osteosarcoma incidence and survival rates from 1973 to 2004: data from the Surveillance, Epidemiology, and End Results Program.
Osteosarcoma incidence and survival rates from 1973 to 2004: data from the Surveillance, Epidemiology, and End Results Program.
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DOI：
10.1002/cncr.24121
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发表时间：
2009-04-01
期刊：
影响因子：
6.2
通讯作者：
Savage, Sharon A.
中科院分区：
文献类型：
--
作者：
Mirabello, Lisa;Troisi, Rebecca J.;Savage, Sharon A.
骨肉瘤是最常见的原发性骨肿瘤，最常发生在青少年，但在60岁以上的人群中存在第二个发病高峰。大多数骨肉瘤流行病学研究都是对所有骨肿瘤的大型分析，或者集中在青春期发生的病例。骨肉瘤发病率和生存率的详细描述，特别是在所有年龄和种族的受试者之间的直接比较，是不可用的。从1973年到2004年，美国国家癌症研究所基于人群的监测、流行病学和最终结果（SEER）项目中，3,482例骨肉瘤患者的频率、发病率和生存率按年龄（0-24岁、25-59岁和60-85岁以上）、种族、性别、病理亚型、分期和解剖部位列出。不同年龄组的发病率和存活率差异很大。最年轻的病例中骨肉瘤的发病率在其他种族中最高，而在中年和老年患者中分别在黑人和白人中最高。老年人骨肉瘤合并佩吉特病和骨肉瘤为第二或更大的癌症的比例很高。注意到不同年龄组之间的肿瘤部位差异。生存率因解剖部位和疾病分期而异，从1984年到2004年没有显著改善。这种全面的、基于人群的骨肉瘤描述，确定了不同年龄组在发病率、生存率、病理亚型和解剖部位方面的重要差异，并量化了骨肉瘤在佩吉特病中或作为第二种癌症对发病率和死亡率的影响。这些发现可能对理解骨肉瘤生物学和流行病学有意义。
Osteosarcoma, the most common primary bone tumor, occurs most frequently in adolescents, but a second incidence peak among individuals over age 60 exists. Most osteosarcoma epidemiology studies have been embedded in large analyses of all bone tumors, or focused on cases occurring in adolescence. Detailed descriptions of osteosarcoma incidence and survival specifically, with direct comparisons among subjects of all ages and ethnicities, are not available. Frequency, incidence and survival rates for 3,482 patients with osteosarcoma from the National Cancer Institute’s population-based Surveillance, Epidemiology, and End Results (SEER) program between 1973 and 2004 are presented by age (0–24, 25–59, and 60–85+ years), race, sex, pathology subtype, stage, and anatomic site. There were large differences in incidence and survival rates by age. Osteosarcoma incidence in the youngest cases was greatest in the Other race designation, while it was greatest in Blacks and Whites in the middle age and elderly patients, respectively. There was a high percentage of osteosarcoma with Paget’s disease and osteosarcoma as a second or greater cancer among the elderly. Tumor site differences among age groups were noted. Survival rates varied by anatomic site and disease stage, and have not significantly improved from 1984 to 2004. This comprehensive, population-based description of osteosarcoma, identified important differences in incidence, survival, pathologic subtype, and anatomic site among age groups, and quantified the impact of osteosarcoma in Paget’s disease or as a second cancer on incidence and mortality rates. These findings may have implications in understanding osteosarcoma biology and epidemiology.
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影响因子：
4.5
作者：
Blackwell, JB;Threlfall, TJ;McCaul, KA
通讯作者：
McCaul, KA
DOI：
10.1097/01.mph.0000161762.53175.e4
发表时间：
2005-04-01
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作者：
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作者：
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作者：
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通讯作者：
CZERNIAK, B