Gastroenteritis and transmission of Helicobacter pylori infection in households.
Gastroenteritis and transmission of Helicobacter pylori infection in households.
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DOI：
10.3201/eid1211.060086
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发表时间：
2006-11
影响因子：
11.8
通讯作者：
Parsonnet J
中科院分区：
文献类型：
--
作者：
Perry S;de la Luz Sanchez M;Yang S;Haggerty TD;Hurst P;Perez-Perez G;Parsonnet J
在加利福尼亚州北部的家庭中，在感染幽门螺杆菌的接触者中暴露于胃肠炎，显著增加了幽门螺杆菌的感染。幽门螺杆菌感染的传播方式缺乏特征性。在加利福尼亚州北部，2752名家庭成员在基线访问时和3个月后接受了血清或粪便中幽门螺杆菌感染的检测。在基线水平被认为未感染的1,752人中，发生了30例新感染(7例确诊，7例可能，16例可能)，年总发病率为7%，2岁以下儿童发病率为21%。暴露于患有胃肠炎的受感染家庭成员会使确诊或可能的新感染风险增加4.8倍(95%可信区间[CI]1.4-17.1)，呕吐的风险因素(调整后的优势比[AOR]6.3，CI 1.6-24.5)比单纯腹泻(AOR 3.0，p=0.65)更大。在可能或确定的新感染中，75%可归因于接触患有胃肠炎的感染者。与患有胃肠炎的幽门螺杆菌感染者接触，特别是呕吐，显著增加新感染的风险。
In northern California homes, exposure to gastroenteritis in an H. pylori–infected contact markedly increased H. pylori infection. The mode of transmission of Helicobacter pylori infection is poorly characterized. In northern California, 2,752 household members were tested for H. pylori infection in serum or stool at a baseline visit and 3 months later. Among 1,752 person considered uninfected at baseline, 30 new infections (7 definite, 7 probable, and 16 possible) occurred, for an annual incidence of 7% overall and 21% in children <2 years of age. Exposure to an infected household member with gastroenteritis was associated with a 4.8-fold (95% confidence interval [CI] 1.4–17.1) increased risk for definite or probable new infection, with vomiting a greater risk factor (adjusted odds ratio [AOR] 6.3, CI 1.6–24.5) than diarrhea only (AOR 3.0, p = 0.65). Of probable or definite new infections, 75% were attributable to exposure to an infected person with gastroenteritis. Exposure to an H. pylori–infected person with gastroenteritis, particularly vomiting, markedly increased risk for new infection.
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影响因子：
11.8
作者：
Perry S;de la Luz Sanchez M;Hurst PK;Parsonnet J
通讯作者：
Parsonnet J
影响因子：
158.5
作者：
DRUMM, B;PEREZPEREZ, GI;SHERMAN, PM
通讯作者：
SHERMAN, PM
影响因子：
24.5
作者：
Graham, DY;Opekun, AR;Monath, TP
通讯作者：
Monath, TP
影响因子：
6.4
作者：
Everhart, JE;Kruszon-Moran, D;McQuillan, G
通讯作者：
McQuillan, G
影响因子：
168.9
作者：
Goodman, KJ;Correa, P
通讯作者：
Correa, P