Impact of Prefrontal Theta Burst Stimulation on Clinical Neuropsychological Tasks.
Impact of Prefrontal Theta Burst Stimulation on Clinical Neuropsychological Tasks.
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DOI：
10.3389/fnins.2017.00462
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发表时间：
2017
影响因子：
4.3
通讯作者：
Marron EM
中科院分区：
文献类型：
--
作者：
Viejo-Sobera R;Redolar-Ripoll D;Boixadós M;Palaus M;Valero-Cabré A;Marron EM
Theta爆发刺激（TBS）协议在神经心理康复中具有很高的前景。然而，他们的能力，无论是减少（连续，cTBS）或增加（间歇性，iTBS）皮质兴奋性的区域以外的主要运动皮层，其一致性调节人类行为与临床相关的任务仍然有待充分建立。TBS对背外侧前额叶皮层（dlPFC）的行为影响特别有趣，因为它参与了工作记忆（WM）和执行功能（EF），通常在额叶脑损伤后受损。我们的目的是探索cTBS和iTBS调节健康个体的WM和EF的能力，用临床神经心理学测试（数字向后，3-back任务，Stroop测试和河内塔）进行评估。为此，36名参与者在刺激前1周以及在cTBS、iTBS或假TBS的单次会话后立即使用四项测试进行评估，这些测试被递送到左侧dlPFC。在任何临床任务的刺激条件下均未发现显著差异。尽管如此，在其中一些，主动刺激诱导显着的前/后性能调制，这是没有发现的假条件。更具体地说，假刺激产生了改善的3-回任务和颜色，颜色词，干扰分数的Stroop测试，一个效果可能是由任务的做法。iTBS和cTBS两者都产生了数字向后的改善和3-back任务准确性的损害。此外，iTBS提高了Stroop测试中的干扰分数，尽管改善了单词阅读和受损的颜色命名，而cTBS减少了完成河内塔所需的时间。与报告的初级运动皮质脊髓测量的TBS结局不同，我们的分析未显示刺激方案之间的任何预期性能差异。然而，如果一个独立的考虑前/后的差异，每个人的结果措施和任务，一个或两个积极的协议似乎调制WM和EF。我们批判性地讨论的价值，潜在的解释，和一些似是而非的解释，这一套微妙的影响，左dlPFC TBS在人类。
Theta burst stimulation (TBS) protocols hold high promise in neuropsychological rehabilitation. Nevertheless, their ability to either decrease (continuous, cTBS) or increase (intermittent, iTBS) cortical excitability in areas other than the primary motor cortex, and their consistency modulating human behaviors with clinically relevant tasks remain to be fully established. The behavioral effects of TBS over the dorsolateral prefrontal cortex (dlPFC) are particularly interesting given its involvement in working memory (WM) and executive functions (EF), often impaired following frontal brain damage. We aimed to explore the ability of cTBS and iTBS to modulate WM and EF in healthy individuals, assessed with clinical neuropsychological tests (Digits Backward, 3-back task, Stroop Test, and Tower of Hanoi). To this end, 36 participants were assessed using the four tests 1 week prior to stimulation and immediately following a single session of either cTBS, iTBS, or sham TBS, delivered to the left dlPFC. No significant differences were found across stimulation conditions in any of the clinical tasks. Nonetheless, in some of them, active stimulation induced significant pre/post performance modulations, which were not found for the sham condition. More specifically, sham stimulation yielded improvements in the 3-back task and the Color, Color-Word, and Interference Score of the Stroop Test, an effect likely caused by task practice. Both, iTBS and cTBS, produced improvements in Digits Backward and impairments in 3-back task accuracy. Moreover, iTBS increased Interference Score in the Stroop Test in spite of the improved word reading and impaired color naming, whereas cTBS decreased the time required to complete the Tower of Hanoi. Differing from TBS outcomes reported for cortico-spinal measures on the primary motor cortex, our analyses did not reveal any of the expected performance differences across stimulation protocols. However, if one considers independently pre/post differences for each individual outcome measure and task, either one or both of the active protocols appeared to modulate WM and EF. We critically discuss the value, potential explanations, and some plausible interpretations for this set of subtle impacts of left dlPFC TBS in humans.
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影响因子：
2
作者：
Christov-Moore L;Sugiyama T;Grigaityte K;Iacoboni M
通讯作者：
Iacoboni M
DOI：
10.1111/ejn.12584
发表时间：
2014-06
期刊：
The European journal of neuroscience
影响因子：
--
作者：
Fried PJ;Rushmore RJ 3rd;Moss MB;Valero-Cabré A;Pascual-Leone A
通讯作者：
Pascual-Leone A
影响因子：
10.6
作者：
Barr, Mera S.;Farzan, Faranak;Daskalakis, Zafiris J.
通讯作者：
Daskalakis, Zafiris J.
DOI：
10.1016/j.cortex.2012.05.022
发表时间：
2013-05
期刊：
Cortex; a journal devoted to the study of the nervous system and behavior
影响因子：
--
作者：
Barbey AK;Koenigs M;Grafman J
通讯作者：
Grafman J
DOI：
10.1016/j.pnpbp.2015.11.009
发表时间：
2016-04-03
影响因子：
5.6
作者：
Cheng, Chih-Ming;Juan, Chi-Hung;Li, Cheng-Ta
通讯作者：
Li, Cheng-Ta