Causal evidence supporting functional dissociation of verbal and spatial working memory in the human dorsolateral prefrontal cortex.
Causal evidence supporting functional dissociation of verbal and spatial working memory in the human dorsolateral prefrontal cortex.
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DOI：
10.1111/ejn.12584
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发表时间：
2014-06
期刊：
影响因子：
--
通讯作者：
Pascual-Leone A
中科院分区：
文献类型：
--
作者：
Fried PJ;Rushmore RJ 3rd;Moss MB;Valero-Cabré A;Pascual-Leone A
人类背外侧前额叶皮质(DlPFC)对监测和处理工作记忆中的信息至关重要，但这种贡献是否具有领域特异性仍未确定。神经成像研究表明，双侧dlPFC活动与工作记忆无关，与刺激领域无关，但这种关系的因果关系无法推断。重复经颅磁刺激(RTMS)有可能测试左右dlPFC对语言和空间领域的贡献是否相等，但这是第一次使用离线rTMS暂时调节dlPFC活动来研究任务域和大脑的相互作用。在不同的治疗过程中，20名健康的右撇子成年人接受了左侧dlPFC，右侧dlPFC的1 Hz-rTMS，加上作为对照的顶端。在rTMS前后，使用3-back任务的口头-字母和空间-位置两个版本来评估工作记忆的表现。RTMS后反应时间更快，与任务领域或刺激条件无关，表明练习或其他非特异性效应的影响。为了准确，右侧dlPFC的rTMS，而不是左侧dlPFC或顶点的rtms，导致了一过性分离：空间减少，但言语准确性增加。事后的相关分析发现，这些变化之间没有关系，这表明语言和空间领域的基础在功能上是独立的。随着时间的推移，有一种双分离的趋势，这表明在言语和空间工作记忆的功能组织上存在潜在的侧向性。至少，这些发现为dlPFC对工作记忆的特定领域贡献提供了人类证据，并加强了rTMS改善认知的潜力。
The human dorsolateral prefrontal cortex (dlPFC) is crucial for monitoring and manipulating information in working memory, but whether such contributions are domain-specific remains unsettled. Neuroimaging studies have shown bilateral dlPFC activity associated with working memory independent of stimulus domain, but the causality of this relationship cannot be inferred. Repetitive transcranial magnetic stimulation (rTMS) has the potential to test whether the left and right dlPFC contribute equally to verbal and spatial domains, however this is the first study to investigate the interaction of task domain and hemisphere using offline rTMS to temporarily modulate dlPFC activity. In separate sessions, twenty healthy right-handed adults received 1Hz-rTMS to left dlPFC, right dlPFC, plus the vertex as a control site. Working memory performance was assessed pre- and post-rTMS using both verbal-‘letter’ and spatial-‘location’ versions of the 3-back task. Response times were faster post-rTMS, independent of task domain or stimulation condition, indicating the influence of practice or other nonspecific effects. For accuracy, rTMS of the right dlPFC, but not the left dlPFC or vertex, led to a transient dissociation: reducing spatial, but increasing verbal accuracy. A post-hoc correlation analysis found no relationship between these changes indicating the substrates underlying verbal and spatial domains are functionally independent. Collapsing across time, there was a trend towards a double dissociation, suggesting a potential laterality in functional organization of verbal and spatial working memory. At a minimum, these findings provide human evidence for domain-specific contributions of the dlPFC to working memory and reinforce the potential of rTMS to ameliorate cognition.
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影响因子：
2.5
作者：
D'Esposito, M;Postle, BR;Lease, J
通讯作者：
Lease, J
影响因子：
3.7
作者：
Fried PJ;Elkin-Frankston S;Rushmore RJ;Hilgetag CC;Valero-Cabre A
通讯作者：
Valero-Cabre A
DOI：
10.1016/j.cortex.2012.05.022
发表时间：
2013-05
期刊：
Cortex; a journal devoted to the study of the nervous system and behavior
影响因子：
--
作者：
Barbey AK;Koenigs M;Grafman J
通讯作者：
Grafman J
影响因子：
9.9
作者：
Boroojerdi, B;Prager, A;Cohen, LG
通讯作者：
Cohen, LG
影响因子：
7.6
作者：
Barr, Mera S.;Farzan, Faranak;Daskalakis, Zafiris J.
通讯作者：
Daskalakis, Zafiris J.