Combined Effects of Drugs and Plasticizers on the Properties of Drug Delivery Films.
Combined Effects of Drugs and Plasticizers on the Properties of Drug Delivery Films.
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DOI：
10.1177/0883911515627178
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发表时间：
2016-07
影响因子：
1.7
通讯作者：
Puleo DA
中科院分区：
文献类型：
--
作者：
Jennings CL;Dziubla TD;Puleo DA
如果对伤口进行局部治疗，结合适应不同愈合阶段的分子，引导组织沿着无疤痕的路径再生，疤痕组织的形成可能会减少或防止。为此，由邻苯二甲酸酯醋酸纤维素和Pluronic F-127制成的药物传递装置装载槲皮素或吡非尼酮，并用柠檬酸三乙酯（TEC）或柠檬酸三丁酯（TBC）进行塑化。槲皮素抑制氧化应激，吡非尼酮已被证明可以减少促炎和纤维化分子的产生。研究了药物和增塑剂对给药膜的侵蚀、释放和力学性能的影响。含有槲皮素的tec塑化膜比TBC膜释放药物的速度慢。负载吡非尼酮的薄膜释放药物的速度比两种增塑剂的腐蚀速度都快。增塑剂TEC和TBC含量的增加增加了伸长率，降低了弹性模量。相比之下，在TEC和TBC薄膜中增加吡非尼酮的负载导致了显著更高的模量，这是一种抗增塑剂作用。添加吡非尼酮显著降低了所有类型薄膜的伸长率，但随着药物含量的增加，槲皮素负载的样品伸长率显著提高。含有槲皮素的薄膜比含有吡非尼酮的薄膜拉长。槲皮素比吡非尼酮大1.5倍以上，水溶性比吡非尼酮低12倍以上，结合位点比吡非尼酮多6倍。这些差异影响了两种药物如何与邻苯二甲酸酯纤维素和Pluronic F-127相互作用，从而决定了聚合物的性质。结合聚合物薄膜的药物释放、侵蚀和机械性能可以根据系统中包含的药物和增塑剂的特性来定制。
Formation of scar tissue may be reduced or prevented if wounds were locally treated with a combination of molecules tuned to the different healing phases, guiding tissue regeneration along a scar free path. To this end, drug delivery devices made of cellulose acetate phthalate and Pluronic F-127 were loaded with either quercetin or pirfenidone and plasticized with either triethyl citrate (TEC) or tributyl citrate (TBC). Quercetin inhibits oxidative stress, and pirfenidone has been shown to reduce production of pro-inflammatory and fibrogenic molecules. The combined effects of drug and plasticizer on erosion, release, and mechanical properties of the drug delivery films were investigated. TEC-plasticized films containing quercetin released drug at a slower rate than did TBC films. Pirfenidone-loaded films released drug at a faster rate than erosion occurred for both types of plasticizers. Higher plasticizer contents of both TEC and TBC increased the elongation and decreased the elastic modulus. In contrast, increased pirfenidone loading in both TEC and TBC films resulted in a significantly higher modulus, an anti-plasticizer effect. Adding pirfenidone significantly decreased elongation for all film types, but quercetin-loaded samples had significantly greater elongation with increasing drug content. Films containing quercetin elongated more than did pirfenidone-loaded films. Quercetin is over 1.5 times larger than pirfenidone, has water solubility over 12 times lower, and has 6 times more bonding sites than pirfenidone. These differences affected how the two drugs interacted with cellulose acetate phthalate and Pluronic F-127 and thereby determined polymer properties. Drug release, erosion, and mechanical properties of association polymer films can be tailored by the characteristics of the drugs and plasticizers included in the system.
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影响因子：
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作者：
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通讯作者：
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作者：
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影响因子：
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Kim YS;Lew DH;Tark KC;Rah DK;Hong JP
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Hong JP