O-acetylation of GD3: an enigmatic modification regulating apoptosis?
O-acetylation of GD3: an enigmatic modification regulating apoptosis?
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DOI：
10.1084/jem.20021915
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发表时间：
2002-12-16
期刊：
影响因子：
--
通讯作者：
Varki A
中科院分区：
文献类型：
--
作者：
Chen HY;Varki A
鞘糖脂（GSL）是一种两亲性分子，具有极性聚糖链作为头基和疏水性含鞘氨醇的神经酰胺尾，其通常嵌入质膜的外小叶中（1）。GSL不再被认为仅仅是膜的物理成分。它们通常聚集在“糖信号结构域”（GSD;参考文献2）中，有时沿着其他鞘脂、糖基磷脂酰肌醇（GPI）锚定蛋白和胆固醇，形成“脂筏”（3）。这些微区被认为通过与信号转导分子的顺式相互作用来调节信号转导。最近已显示称为Gd 3的GSL参与造血细胞中Fas介导的细胞凋亡，导致线粒体电位丧失和细胞凋亡因子释放（综述见参考文献4和5）。在这个问题上，Malisan et al. (6)表明天然存在的Gd 3修饰（O-乙酰化）可以逆转其凋亡作用，这表明细胞可以避免Gd 3诱导凋亡的命运。为了更好地理解这个有趣的故事，首先有必要回顾一些关于Gd 3和O-乙酰化的一般信息。
Glycosphingolipids (GSLs) are amphipathic molecules with a polar glycan chain as a head group and a hydrophobic sphingosine-containing ceramide tail, which is typically embedded in the outer leaflet of the plasma membrane (1). GSLs are no longer thought to be mere physical components of the membrane. They often cluster in “glycosignaling domains”(GSDs; reference 2), sometimes along with other sphingolipids, glycosylphosphatidylinositol (GPI)-anchored proteins, and cholesterol, forming “lipid rafts”(3). These microdomains are thought to regulate signal transduction via cis interactions with signal transducer molecules. A GSL called Gd3 has recently been shown to be involved in Fas-mediated apoptosis in hematopoietic cells, causing the loss of mitochondrial potential and the release of apoptotic factors (for reviews, see references 4 and 5). In this issue, Malisan et al.(6) show that a naturally occurring modification of Gd3 (O-acetylation) can reverse its apoptotic effects, suggesting a way for cells to avoid the fate of Gd3-induced apoptosis. To understand this interesting story better, it is first necessary to review some general information about Gd3 and O-acetylation.
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DOI：
10.1084/jem.180.4.1547
发表时间：
1994-10-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Cifone MG;De Maria R;Roncaioli P;Rippo MR;Azuma M;Lanier LL;Santoni A;Testi R
通讯作者：
Testi R
影响因子：
3.5
作者：
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通讯作者：
Malorni, W
影响因子：
4.7
作者：
Birklé, S;Ren, SL;Yu, RK
通讯作者：
Yu, RK
影响因子：
56.9
作者：
CHERESH, DA;REISFELD, RA;VARKI, AP
通讯作者：
VARKI, AP
DOI：
10.1073/pnas.82.4.1242
发表时间：
1985-01-01
影响因子：
11.1
作者：
HOUGHTON, AN;MINTZER, D;OLD, LJ
通讯作者：
OLD, LJ