Effects of early life adversity on maternal effort and glucocorticoids in wild olive baboons
Effects of early life adversity on maternal effort and glucocorticoids in wild olive baboons
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早年逆境对野生橄榄狒狒母性努力和糖皮质激素的影响
DOI：
10.1007/s00265-021-03056-7
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发表时间：
2021
影响因子：
2.3
通讯作者：
Silk, Joan B.
中科院分区：
文献类型：
--
作者：
Patterson, Sam K.;Hinde, Katie;Bond, Angela B.;Trumble, Benjamin C.;Strum, Shirley C.;Silk, Joan B.
生命早期的不良经历对发育、健康、生殖和社会关系产生重要影响，其后果往往持续几代人。母亲的早期生活经历可以通过多种途径影响其后代的发育，例如母亲护理，通过糖皮质激素的生理信号，甚至是表观遗传等代际效应。雌性黄狒狒（Papio cynocephalus）的早期生活逆境预测糖皮质激素升高，社会性降低，寿命缩短，后代死亡率较高。如果狒狒母亲有更多的早期生活逆境，经历更差的条件和斗争，以提供他们的后代，这可能有助于持续的跨代逆境的影响。在这里，我们在一群橄榄狒狒（Papio anubis）中研究了母亲的早期生活逆境对她们的母性努力、生理和后代生存能力的影响。在自己的早期发育中经历更多逆境的母亲表现出更大的母性努力（即，花更多的时间护理和携带），并有更高水平的糖皮质激素代谢物比母亲较少的早期生活逆境。与早期生活逆境较少的母亲的后代相比，早期生活逆境较多的母亲的后代的生存能力降低。没有证据表明母亲的高社会地位缓冲了早期生活逆境的影响。我们的数据表明，早期的生活经验可以有持久的后果，对产妇的努力和生理，这可能会作为近机制的代际影响的孕产妇experience.Significance statementAnimals暴露于早期生活逆境的经验，立即和持久的后果。如果早期生活逆境施加发展限制，影响母亲供养后代的能力，这可以解释早期生活逆境的跨代影响。在我们对野生橄榄狒狒的研究中，我们研究了母亲自己的早期生活逆境如何预测她的母性努力（即，哺乳和携带时间）、母体粪便糖皮质激素水平和后代结果。我们发现，经历了更多的早期生活逆境的雌性狒狒在怀孕和哺乳期间有更高的糖皮质激素水平，发挥更多的母亲的努力，并产生后代的死亡风险比女性更少的早期生活逆境。我们的研究结果表明，具有更多早期生活逆境的雌性狒狒经历了发育限制，并努力投资于后代，这可能有助于几代人的早期生活逆境的持续影响。
AbstractAdverse experiences during early life exert important effects on development, health, reproduction, and social bonds, with consequences often persisting across generations. A mother’s early life experiences can impact her offspring’s development through a number of pathways, such as maternal care, physiological signaling through glucocorticoids, or even intergenerational effects like epigenetic inheritance. Early life adversity in female yellow baboons (Papio cynocephalus) predicts elevated glucocorticoids, reduced sociality, shortened lifespan, and higher offspring mortality. If baboon mothers with more early life adversity, experience poorer condition and struggle to provide for their offspring, this could contribute to the persisting transgenerational effects of adversity. Here, we examined the effects of mothers’ early life adversity on their maternal effort, physiology, and offspring survivability in a population of olive baboons,Papio anubis.Mothers who experienced more adversity in their own early development exerted greater maternal effort (i.e., spent more time nursing and carrying) and had higher levels of glucocorticoid metabolites than mothers with less early life adversity. Offspring of mothers with more early life adversity had reduced survivability compared to offspring of mothers with less early life adversity. There was no evidence that high maternal social rank buffered the effects of early life adversity. Our data suggest early life experiences can have lasting consequences on maternal effort and physiology, which may function as proximate mechanisms for intergenerational effects of maternal experience.Significance statementAnimals exposed to early life adversity experience both immediate and lasting consequences. If early life adversity exerts developmental constraints that affect a mother’s ability to provide for her offspring, this could explain the transgenerational effects of early life adversity. In our study of wild olive baboons, we examined how a mother’s own early life adversity predicts her maternal effort (i.e., nursing and carrying time), maternal fecal glucocorticoid levels, and offspring outcomes. We found that female baboons who experienced more early life adversity had higher glucocorticoid levels during pregnancy and lactation, exerted more maternal effort, and produced offspring with higher mortality risk than females with less early life adversity. Our results suggest that female baboons with more early life adversity experience developmental constraints and struggle to invest in offspring, which likely contributes to persisting effects of early life adversity across generations.
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多种野生灵长类动物的孕产妇死亡和后代健康
DOI：
10.1073/pnas.2015317118
发表时间：
2020
期刊：
Proceedings of the National Academy of Sciences
影响因子：
--
作者：
Zipple, Matthew N.;Altmann, Jeanne;Campos, Fernando A.;Cords, Marina;Fedigan, Linda M.;Lawler, Richard R.;Lonsdorf, Elizabeth V.;Perry, Susan;Pusey, Anne E.;Stoinski, Tara S.
通讯作者：
Stoinski, Tara S.
橄榄狒狒（Papio anubis）的繁殖力随年龄和环境的变化
影响因子：
2.4
作者：
S. Strum;Jonah D. Western
通讯作者：
Jonah D. Western
影响因子：
3.7
作者：
Hinde, Katie;Milligan, Lauren A.
通讯作者：
Milligan, Lauren A.
影响因子：
3.6
作者：
HUCK, UW;LABOV, JB;LISK, RD
通讯作者：
LISK, RD
首次生殖年龄：恒河猴（Macaca mulatta）哺乳期、婴儿质量和随后繁殖的发育预测因素和后果。
影响因子：
2.8
作者：
Pittet,Florent;Johnson,Crystal;Hinde,Katie
通讯作者：
Hinde,Katie