Frequency-specific network connectivity increases underlie accurate spatiotemporal memory retrieval.
Frequency-specific network connectivity increases underlie accurate spatiotemporal memory retrieval.
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DOI：
10.1038/nn.3315
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发表时间：
2013-03
影响因子：
25
通讯作者：
Ekstrom, Arne D.
中科院分区：
文献类型：
--
作者：
Watrous, Andrew J.;Tandon, Nitin;Conner, Chris R.;Pieters, Thomas;Ekstrom, Arne D.
内侧颞叶、前额叶皮层和部分顶叶皮层构成了情景记忆的神经基础，其中包括记住事件发生的地点和时间。然而，这三个关键区域在空间和时间上下文检索过程中如何相互作用仍然很大程度上未经测试。在这里，我们采用跨多个小叶区域的同步皮层电图记录，采用相位同步作为网络功能连接的衡量标准，同时患者检索与发作相关的空间和时间背景。与错误的记忆检索相比，成功的记忆检索的特点是全局连接性更强，MTL 充当这些交互的汇聚中心。空间与时间上下文检索导致网络交互的频谱和时间模式存在显着差异。这些结果强调动态网络交互是情景记忆检索的核心，为如何在同一网络中重新创建单个事件背后的多个上下文提供了新颖的见解。
The medial temporal lobes, prefrontal cortex, and parts of parietal cortex form the neural underpinnings of episodic memory, which includes remembering both where and when an event occurred. Yet how these three key regions interact during retrieval of spatial and temporal context remains largely untested. Here, we employed simultaneous electrocorticographical recordings across multiple lobular regions, employing phase synchronization as a measure of network functional connectivity, while patients retrieved spatial and temporal context associated with an episode. Successful memory retrieval was characterized by greater global connectivity compared to incorrect retrieval, with the MTL acting as a convergence hub for these interactions. Spatial vs. temporal context retrieval resulted in prominent differences in both the spectral and temporal patterns of network interactions. These results emphasize dynamic network interactions as central to episodic memory retrieval, providing novel insight into how multiple contexts underlying a single event can be recreated within the same network.
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