Aberrant Temporal Connectivity in Persons at Clinical High Risk for Psychosis.
Aberrant Temporal Connectivity in Persons at Clinical High Risk for Psychosis.
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DOI：
10.1016/j.bpsc.2016.12.008
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发表时间：
2017-11
期刊：
影响因子：
--
通讯作者：
Peterson BS
中科院分区：
文献类型：
--
作者：
Colibazzi T;Yang Z;Horga G;Chao-Gan Y;Corcoran CM;Klahr K;Brucato G;Girgis R;Abi-Dargham A;Milham MP;Peterson BS
精神分裂症是一种神经发育障碍，涉及分布式神经网络的功能连接（FC）异常，这被认为是早于精神病的出现。在一组处于精神病临床高风险（Psychosis）的青少年和年轻人中，我们应用数据驱动方法对静息状态fMRI数据进行了系统描述，以系统地描述在此期间FC异常的特征，并确定这些异常是否与精神病风险和精神病症状的严重程度相关。我们的分析中包括51名参与者和47名匹配的健康对照（HC）。其中12名参与者在3.9年内患上了精神病。我们估计了FC的一个多变量测量，并研究了其与抑郁状态、向精神病的转化和阳性症状严重程度的关系。多变量分析揭示了双侧颞区全脑连接模式的组间差异，主要影响其与丘脑的功能连接。此外，更严重的阳性症状与前扣带回和额叶皮层的连接异常有关。我们的研究表明，在精神分裂症中观察到的丘脑和颞叶区域的已确立的FC异常也存在于精神分裂症期间，颞叶皮层的异常连接与精神病风险最相关。
Schizophrenia, a neurodevelopmental disorder, involves abnormalities in functional connectivity (FC) across distributed neural networks, which are thought to antedate the emergence of psychosis. In a cohort of adolescents and young adults at clinical high risk (CHR) for psychosis, we applied data-driven approaches to resting-state fMRI data so as to systematically characterize FC abnormalities during this period and determine whether these abnormalities are associated with psychosis risk and severity of psychotic symptoms. Fifty-one CHR participants and 47 matched healthy controls (HCs) were included in our analyses. Twelve of these CHR participants developed psychosis within 3.9 years. We estimated one multivariate measure of FC and studied its relationship to CHR status, conversion to psychosis and positive symptom severity. Multivariate analyses revealed between-group differences in whole-brain connectivity patterns of bilateral temporal areas, mostly affecting their functional connections to the thalamus. Further, more severe positive symptoms were associated with greater connectivity abnormalities in the anterior cingulate and frontal cortex. Our study demonstrates that the well-established FC abnormalities of the thalamus and temporal areas observed in schizophrenia are also present in the CHR period, with aberrant connectivity of the temporal cortex most associated with psychosis risk.
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在认知控制性能过程中，第一期精神分裂症中的一般和特定的功能连通性干扰。
影响因子：
10.6
作者：
Fornito, Alex;Yoon, Jong;Zalesky, Andrew;Bullmore, Edward T.;Carter, Cameron S.
通讯作者：
Carter, Cameron S.
初次用药精神病中的网络级脱节：分离跨诊断和诊断特异性改变
DOI：
10.1038/npp.2016.247
发表时间：
2017-03
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
Gong Q;Hu X;Pettersson-Yeo W;Xu X;Lui S;Crossley N;Wu M;Zhu H;Mechelli A
通讯作者：
Mechelli A
影响因子：
6.6
作者：
Allen, Paul;Luigjes, Judy;McGuire, Philip
通讯作者：
McGuire, Philip
影响因子：
4.8
作者：
Fornito, Alex;Yucel, Murat;Panteliss, Christos
通讯作者：
Panteliss, Christos
影响因子：
5.4
作者：
Bedi, Gillinder;Carrillo, Facundo;Corcoran, Cheryl M.
通讯作者：
Corcoran, Cheryl M.