Using omics approaches to dissect the therapeutic effects of Chinese herbal medicines on gastrointestinal cancers.
Using omics approaches to dissect the therapeutic effects of Chinese herbal medicines on gastrointestinal cancers.
复制标题
DOI：
10.3389/fphar.2022.884822
复制
发表时间：
2022
影响因子：
5.6
通讯作者：
Hong, Ming
中科院分区：
文献类型：
--
作者：
Li, Si-Yi;Wang, Wei-Jia;Li, Qiu-Yue;Yang, Peng-Hui;Li, Xin-Long;Yan, Yan;Yuan, Yong;Feng, Yi-Bin;Hong, Ming
中草药提供了丰富的抗癌药物来源。中草药药理学与现代合成化学品之间的差异阻碍了草药产品药物的开发。为了应对这一挑战，包括转录组学、蛋白质组学、基因组学、代谢组学和微生物组学在内的新型组学方法已被应用于剖析中草药在癌症治疗中的药理益处。许多中草药对不同的胃肠道（GI）癌症显示出潜在的抗肿瘤作用，同时消除了传统癌症治疗的副作用。本研究旨在概述基于组学方法的中草药治疗胃肠道癌症的最新研究。这篇综述还说明了组学方法在草药衍生药物发现中的潜在效用。组学方法可以准确有效地揭示中草药治疗胃肠道癌症的关键分子靶点和细胞内相互作用网络。本研究总结了不同组学方法在研究中草药对胃肠道癌症的作用和机制中的应用。还提出了该研究领域的未来研究方向。
Chinese herbal medicines offer a rich source of anti-cancer drugs. Differences between the pharmacology of Chinese herbal medicines and modern synthetic chemicals hinder the development of drugs derived from herbal products. To address this challenge, novel omics approaches including transcriptomics, proteomics, genomics, metabolomics, and microbiomics have been applied to dissect the pharmacological benefits of Chinese herbal medicines in cancer treatments. Numerous Chinese herbal medicines have shown potential anti-tumor effects on different gastrointestinal (GI) cancers while eliminating the side effects associated with conventional cancer therapies. The present study aimed to provide an overview of recent research focusing on Chinese herbal medicines in GI cancer treatment, based on omics approaches. This review also illustrates the potential utility of omics approaches in herbal-derived drug discovery. Omics approaches can precisely and efficiently reveal the key molecular targets and intracellular interaction networks of Chinese herbal medicines in GI cancer treatment. This study summarizes the application of different omics-based approaches in investigating the effects and mechanisms of Chinese herbal medicines in GI cancers. Future research directions are also proposed for this area of study.
登录
查看更多内容
影响因子：
5.6
作者：
Kim, Seong-Hun;Jin, Hua;Kim, Soo Mi
通讯作者：
Kim, Soo Mi
影响因子：
5.4
作者：
Geisen U;Zenthoefer M;Peipp M;Kerber J;Plenge J;Managò A;Fuhrmann M;Geyer R;Hennig S;Adam D;Piker L;Rimbach G;Kalthoff H
通讯作者：
Kalthoff H
影响因子：
5.6
作者：
Chen Y;Gao Y;Yi X;Zhang J;Chen Z;Wu Y
通讯作者：
Wu Y
影响因子：
5.4
作者：
Daddiouaissa, Djabir;Amid, Azura;Elnour, Ahmed A. M.
通讯作者：
Elnour, Ahmed A. M.
影响因子：
4.6
作者：
Gnocchi D;Del Coco L;Girelli CR;Castellaneta F;Cesari G;Sabbà C;Fanizzi FP;Mazzocca A
通讯作者：
Mazzocca A