Comparison of Rift Valley fever virus replication in North American livestock and wildlife cell lines.
Comparison of Rift Valley fever virus replication in North American livestock and wildlife cell lines.
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DOI：
10.3389/fmicb.2015.00664
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发表时间：
2015
影响因子：
5.2
通讯作者：
Wilson WC
中科院分区：
文献类型：
--
作者：
Gaudreault NN;Indran SV;Bryant PK;Richt JA;Wilson WC
裂谷热病毒（RVFV）在整个非洲和阿拉伯半岛引起疾病暴发，导致年幼家畜的高发病率和死亡率，怀孕动物的频繁流产，以及人类的潜在严重或致命疾病。RVFV传播到美国或世界其他国家的可能性对动物和公共卫生，畜牧业生产和贸易具有重大意义。RVFV在流行间隔期持续存在的机制可能是通过蚊子跨卵传播和/或通过野生动物水库。在流行地区的实地调查和先前的体内研究表明，RVFV可以感染广泛的动物，包括非洲的土著野生反刍动物。然而，没有占主导地位的野生动物水库已被确定，我们的知识的RVFV许可主机的差距仍然存在。在北美，家养山羊、绵羊和牛是RVFV的易感宿主，并且存在几种感受态载体。鹿等野生反刍动物可能是病毒的储存库，鉴于其数量丰富，分布广泛，与畜牧场和人类居住区重叠，可能是一个重要的风险因素。本研究的目的是评估来自北美家畜和野生动物的各种细胞系对RVFV的敏感性和容许性。这项研究的结果表明，RVFV可能复制本地鹿种，如白尾鹿，并可能广泛的非反刍动物。这项工作有助于指导和支持未来的动物模型研究和风险模型评估这一高后果的人畜共患病病原体。
Rift Valley fever virus (RVFV) causes disease outbreaks across Africa and the Arabian Peninsula, resulting in high morbidity and mortality among young domestic livestock, frequent abortions in pregnant animals, and potentially severe or fatal disease in humans. The possibility of RVFV spreading to the United States or other countries worldwide is of significant concern to animal and public health, livestock production, and trade. The mechanism for persistence of RVFV during inter-epidemic periods may be through mosquito transovarial transmission and/or by means of a wildlife reservoir. Field investigations in endemic areas and previous in vivo studies have demonstrated that RVFV can infect a wide range of animals, including indigenous wild ruminants of Africa. Yet no predominant wildlife reservoir has been identified, and gaps in our knowledge of RVFV permissive hosts still remain. In North America, domestic goats, sheep, and cattle are susceptible hosts for RVFV and several competent vectors exist. Wild ruminants such as deer might serve as a virus reservoir and given their abundance, wide distribution, and overlap with livestock farms and human populated areas could represent an important risk factor. The objective of this study was to assess a variety of cell lines derived from North American livestock and wildlife for susceptibility and permissiveness to RVFV. Results of this study suggest that RVFV could potentially replicate in native deer species such as white-tailed deer, and possibly a wide range of non-ruminant animals. This work serves to guide and support future animal model studies and risk model assessment regarding this high-consequence zoonotic pathogen.
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DOI：
10.4269/ajtmh.2012.12-0257
发表时间：
2012-12-01
影响因子：
3.3
作者：
Bingham, Andrea M.;Graham, Sean P.;Unnasch, Thomas R.
通讯作者：
Unnasch, Thomas R.
DOI：
10.3390/v3050493
发表时间：
2011-05
期刊：
Viruses
影响因子：
--
作者：
Ikegami T;Makino S
通讯作者：
Makino S
DOI：
10.4269/ajtmh.2008.79.809
发表时间：
2008-11-01
影响因子：
3.3
作者：
Burkett-Cadena, Nathan D.;Graham, Sean P.;Unnasch, Thomas R.
通讯作者：
Unnasch, Thomas R.
影响因子：
11.8
作者：
Hartley DM;Rinderknecht JL;Nipp TL;Clarke NP;Snowder GD;National Center for Foreign Animal and Zoonotic Disease Defense Advisory Group on Rift Valley Fever
通讯作者：
National Center for Foreign Animal and Zoonotic Disease Defense Advisory Group on Rift Valley Fever
影响因子：
2.5
作者：
Blitvich, Bradley J.
通讯作者：
Blitvich, Bradley J.