The pathogenesis of Rift Valley fever.

The pathogenesis of Rift Valley fever.
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DOI:
10.3390/v3050493
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发表时间:
2011-05
期刊:
Viruses
影响因子:
--
通讯作者:
Makino S
Makino S
中科院分区:
其他
文献类型:
--
作者:
Ikegami T;Makino S

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裂谷热是一种新出现的人畜共患疾病,分布于撒哈拉以南非洲国家和阿拉伯半岛。该病是由布尼亚病毒科和白蛉病毒属的裂谷热病毒引起的。该病毒由蚊子传播,病毒在家养反刍动物中的复制导致高死亡率和流产率。人类感染裂谷热病毒通常会引起自限性急性发热性疾病;然而,少数病例发展为神经系统疾病、部分或完全失明、出血热或血栓形成。本文综述了裂谷热在人类患者和几种动物模型中的病理情况,并总结了病毒毒力因素和宿主因素在影响裂谷热发病机制中的作用。
Rift Valley fever (RVF) is an emerging zoonotic disease distributed in sub-Saharan African countries and the Arabian Peninsula. The disease is caused by the Rift Valley fever virus (RVFV) of the family Bunyaviridae and the genus Phlebovirus. The virus is transmitted by mosquitoes, and virus replication in domestic ruminant results in high rates of mortality and abortion. RVFV infection in humans usually causes a self-limiting, acute and febrile illness; however, a small number of cases progress to neurological disorders, partial or complete blindness, hemorrhagic fever, or thrombosis. This review describes the pathology of RVF in human patients and several animal models, and summarizes the role of viral virulence factors and host factors that affect RVFV pathogenesis.
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发表时间: 1980-01-01
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