Environmental chemicals and microRNAs.
Environmental chemicals and microRNAs.
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DOI：
10.1016/j.mrfmmm.2011.05.004
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发表时间：
2011-09-01
影响因子：
2.3
通讯作者：
Baccarelli, Andrea
中科院分区：
文献类型：
--
作者：
Hou, Lifang;Wang, Dong;Baccarelli, Andrea
MicroRNAs （miRNAs）是短的单链非编码分子，其功能是沉默或抑制基因表达的负调节因子。miRNA的异常表达与许多疾病的一些细胞过程和致病途径有关。越来越多的证据表明，miRNA对基因表达的调控可能受到环境化学物质的影响。这些环境暴露包括那些经常与慢性疾病相关的环境，如重金属、空气污染、双酚A和吸烟。在本文中，我们回顾了与暴露于几种环境化学物质有关的miRNA的已发表数据，并讨论了可能将环境化学物质与miRNA改变联系起来的潜在机制。我们进一步讨论了环境mirna研究面临的挑战和可能的未来方向。越来越多的证据将mirna与环境化学物质联系起来，再加上mirna在基因表达中的独特调节作用，使mirna成为更好地了解环境疾病机制的潜在生物标志物。
MicroRNAs (miRNAs) are short single-stranded non-coding molecules that function as negative regulators to silence or suppress gene expression. Aberrant miRNA expression has been implicated in a several cellular processes and pathogenic pathways of a number of diseases. Evidence is rapidly growing that miRNA regulation of gene expression may be affected by environmental chemicals. These environmental exposures include those that have frequently been associated with chronic diseases, such as heavy metals, air pollution, bisphenol A, and cigarette smoking. In this article, we review the published data on miRNAs in relation to the exposure to several environmental chemicals, and discuss the potential mechanisms that may link environmental chemicals to miRNA alterations. We further discuss the challenges in environmental-miRNA research and possible future directions. The cumulating evidence linking miRNAs to environmental chemicals, coupled with the unique regulatory role of miRNAs in gene expression, makes miRNAs potential biomarkers for better understanding the mechanisms of environmental diseases.
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