The Effect of Depression, Generalized Anxiety, and Selective Serotonin Reuptake Inhibitors on Change in Bone Metabolism in Adolescents and Emerging Adults.
The Effect of Depression, Generalized Anxiety, and Selective Serotonin Reuptake Inhibitors on Change in Bone Metabolism in Adolescents and Emerging Adults.
复制标题
DOI：
10.1002/jbmr.3238
复制
发表时间：
2017-12
期刊：
影响因子：
--
通讯作者：
Zemel BS
中科院分区：
文献类型：
--
作者：
Calarge CA;Mills JA;Janz KF;Burns TL;Schlechte JA;Coryell WH;Zemel BS
前瞻性研究重度抑郁症（MDD）、广泛性焦虑症（GAD）和选择性5-羟色胺再摄取抑制剂（SSRIs）的使用对老年青少年和初成人骨代谢变化的独立影响。前瞻性随访了未用药或在开始SSRI后一个月内的15至20岁的医学健康人群。每月评估精神功能和药物治疗。每四个月，评估桡骨骨小梁和皮质体积骨矿物质密度（vBMD）和骨代谢标志物。每8个月，测定全身减去头部区域骨矿物质含量和腰椎（LS）区域BMD。线性混合效应回归分析一方面检查骨测量与MDD、GAD和SSRI指数之间的关联。对264名参与者进行了1.51±0.76年的随访。调整年龄、性别、维生素D浓度、体力活动、瘦体重或握力和研究时间后，MDD严重程度与LS aBMD增加相关。同样，SSRI的使用与女性参与者的LS aBMD和骨形成增加相关。相比之下，SSRI的使用与男性LS aBMD降低相关。在解释抑郁症后，GAD与骨矿化增加独立相关，尽管相关性较弱。在年龄较大的青少年和新兴成人中，MDD和GAD与骨量增加有关，特别是在腰椎和女性中，而SSRI与女性骨量增加有关，但男性骨量减少。
To prospectively examine the independent contribution of major depressive disorder (MDD), generalized anxiety disorder (GAD), and selective serotonin reuptake inhibitors (SSRIs) use to changes in bone metabolism in older adolescents and emerging adults. Medically-healthy 15 to 20 year-olds who were unmedicated or within one month of starting an SSRI were prospectively followed. Psychiatric functioning and medication treatment were assessed monthly. Every four months, trabecular and cortical volumetric bone mineral density (vBMD) at the radius and markers of bone metabolism were evaluated. Every eight months, total body less head areal bone mineral content and lumbar spine (LS) areal BMD were determined. Linear mixed effects regression analysis examined associations between bone measures on the one hand and MDD, GAD, and SSRI indices on the other. Two hundred and sixty four participants were followed for 1.51±0.76 years. After adjusting for age, sex, vitamin D concentration, physical activity, lean mass or grip strength, and time in the study, MDD severity was associated with increasing LS aBMD. Similarly, SSRI use was associated with increasing LS aBMD and bone formation in female participants. In contrast, SSRI use was associated with decreasing LS aBMD in males. After accounting for depression, GAD was independently, albeit weakly, associated with increased bone mineralization. In older adolescents and emerging adults, MDD and GAD are associated with increasing bone mass, particularly in the lumbar spine and in females, while SSRIs are associated with increasing bone mass in females but decreasing bone mass in males.
登录
查看更多内容
影响因子：
6.3
作者：
Rawson KS;Dixon D;Civitelli R;Peterson TR;Mulsant BH;Reynolds CF 3rd;Lenze EJ
通讯作者：
Lenze EJ
影响因子：
3
作者：
Lourenco, Sara;Lucas, Raquel;Barros, Henrique
通讯作者：
Barros, Henrique
影响因子：
8
作者：
Calarge, Chadi A.;Mills, James A.;Zemel, Babette S.
通讯作者：
Zemel, Babette S.
影响因子：
3.8
作者：
Selya AS;Rose JS;Dierker LC;Hedeker D;Mermelstein RJ
通讯作者：
Mermelstein RJ
影响因子：
5.9
作者：
BECK, AT;BROWN, G;STEER, RA
通讯作者：
STEER, RA