Evidence That Parietal Lobe Fatty Acids May Be More Profoundly Affected in Moderate Alzheimer's Disease (AD) Pathology Than in Severe AD Pathology.
Evidence That Parietal Lobe Fatty Acids May Be More Profoundly Affected in Moderate Alzheimer's Disease (AD) Pathology Than in Severe AD Pathology.
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DOI：
10.3390/metabo8040069
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发表时间：
2018-10-26
期刊：
影响因子：
4.1
通讯作者：
Green BD
中科院分区：
文献类型：
--
作者：
Nasaruddin ML;Pan X;McGuinness B;Passmore P;Kehoe PG;Hölscher C;Graham SF;Green BD
Brain is a lipid-rich tissue, and fatty acids (FAs) play a crucial role in brain function, including neuronal cell growth and development. This study used GC-MS to survey all detectable FAs in the human parietal cortex (Brodmann area 7). These FAs were accurately quantified in 27 cognitively normal age-matched controls, 16 cases of moderate Alzheimer’s disease (AD), 30 severe AD, and 14 dementia with Lewy bodies (DLB). A total of 24 FA species were identified. Multiple comparison procedures, using stepdown permutation tests, noted higher levels of 13 FAs but the majority of changes were in moderate AD and DLB, rather than severe AD. Subjects with moderate AD and DLB pathology exhibited significantly higher levels of a number of FAs (13 FAs and 12 FAs, respectively). These included nervonic, lignoceric, cis-13,16-docosadienoic, arachidonic, cis-11,14,17-eicosatrienoic, erucic, behenic, α-linolenic, stearic, oleic, cis-10-heptanoic, and palmitic acids. The similarities between moderate AD and DLB were quite striking—arachidic acid was the only FA which was higher in moderate AD than control, and was not similarly affected in DLB. Furthermore, there were no significant differences between moderate AD and DLB. The associations between each FA and a number of variables, including diagnosis, age, gender, Aβ plaque load, tau load, and frontal tissue pH, were also investigated. To conclude, the development of AD or DLB pathology affects brain FA composition but, intriguingly, moderate AD neuropathology impacts this to a much greater extent. Post-mortem delay is a potential confounding factor, but the findings here suggest that there could be a more dynamic metabolic response in the earlier stages of the disease pathology.
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影响因子：
4.7
作者：
Abu-Saad, K.;Shahar, D. R.;Fraser, D.
通讯作者：
Fraser, D.
影响因子：
2.2
作者：
Patterson E;Wall R;Fitzgerald GF;Ross RP;Stanton C
通讯作者：
Stanton C
DOI：
10.3233/jad-2011-101608
发表时间：
2011
期刊：
Journal of Alzheimer's disease : JAD
影响因子：
--
作者：
Igarashi M;Ma K;Gao F;Kim HW;Rapoport SI;Rao JS
通讯作者：
Rao JS
影响因子：
4.4
作者：
Fraser, Thomas;Tayler, Hannah;Love, Seth
通讯作者：
Love, Seth
DOI：
10.1073/pnas.0334211100
发表时间：
2003-02-18
影响因子：
11.1
作者：
Bagga, D;Wang, L;Reddy, ST
通讯作者：
Reddy, ST