Neuroscience Letters Cerebellar Vermis Contributes to the Extinction of Conditioned Fear
Neuroscience Letters Cerebellar Vermis Contributes to the Extinction of Conditioned Fear
复制标题
小脑蚓部有助于消除条件性恐惧
DOI：
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发表时间：
--
期刊：
影响因子：
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通讯作者：
C. J. Merz
中科院分区：
文献类型：
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作者：
A. Utz;M. Thürling;T. Ernst;A. Hermann;R. Stark;O. T. Wolf;D. Timmann;C. J. Merz
• 重新分析针对小脑的恐惧消退的人类功能磁共振成像研究。 • 蚓部前部在消除条件性恐惧方面发挥着重要作用。 • 小脑可能是消除条件性恐惧的神经回路的一部分。关键词：小脑 恐惧条件反射 恐惧消退 fMRI 小叶 VI 蚓部 摘要 已知小脑有助于获得和保留条件运动和情绪反应。眨眼条件反射和恐惧条件反射已经得到了最详细的研究。尽管大量研究表明小脑也参与了条件性眨眼反应的消退，但小脑对条件性恐惧反应消退的可能贡献在很大程度上被忽视了。在本研究中，我们分析了先前研究 32 名年轻健康男性条件性恐惧消失情况的功能性脑成像数据 (fMRI)，其中事件相关的 fMRI 分析不包括小脑。使用针对小脑优化的空间标准化方法来分析该数据集。在恐惧获得过程中，令人不快的电击（无条件刺激；US）与两张几何图形图片（条件刺激；CS+）中的一张配对，而另一张图片（CS−）从未与US配对。在灭绝过程中，CS+和CS−在没有US的情况下出现。在采集阶段，与后期采集相比，早期半球小叶 VI 中与 CS+ 相关的 fMRI 信号显着较高（p < .05，排列校正）。在消光阶段，与消光晚期相比，早期蚓部前部内与对比度 CS+ > CS− 相关的 fMRI 信号显着较高（p < .05，排列校正）。目前的数据表明，小脑不仅与条件性恐惧的获得有关，还与条件性恐惧的消除有关。
• Re-analysis of a human fMRI study on fear extinction focusing on the cerebellum. • The anterior vermis plays a role in the extinction of conditioned fear. • The cerebellum is likely part of the neural circuitry underlying extinction of conditioned fear. Keywords: Cerebellum Fear conditioning Fear extinction fMRI Lobule VI Vermis a b s t r a c t The cerebellum is known to contribute to the acquisition and retention of conditioned motor and emotional responses. Eyeblink conditioning and fear conditioning have been studied in greatest detail. Whereas a considerable number of studies have shown that the cerebellum is also involved in extinction of conditioned eyeblink responses, the likely contribution of the cerebellum to extinction of conditioned fear responses has largely been ignored. In the present study, we analyzed functional brain imaging data (fMRI) of previous work investigating extinction of conditioned fear in 32 young and healthy men, in which event-related fMRI analysis did not include the cerebellum. This dataset was analyzed using a spatial normalization method optimized for the cerebellum. During fear acquisition, an unpleasant electric shock (unconditioned stimulus; US) was paired with one of two pictures of geometrical figures (conditioned stimulus; CS+), while the other picture (CS−) was never paired with the US. During extinction, CS+ and CS− were presented without the US. During the acquisition phase, the fMRI signal related to the CS+ was significantly higher in hemispheric lobule VI in early compared to late acquisition (p < .05, permutation corrected). During the extinction phase, the fMRI signal related to the contrast CS+ > CS− was significantly higher within the anterior vermis in early compared to late extinction (p < .05, permutation corrected). The present data show that the cerebellum is not only associated with the acquisition but also with the extinction of conditioned fear.
影响因子：
1.9
作者：
PHILLIPS, RG;LEDOUX, JE
通讯作者：
LEDOUX, JE
DOI：
10.1176/appi.ajp.2011.10121780
发表时间：
2012-04
期刊：
The American journal of psychiatry
影响因子：
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作者：
Linnman C;Zeidan MA;Furtak SC;Pitman RK;Quirk GJ;Milad MR
通讯作者：
Milad MR