Resting amygdala and medial prefrontal metabolism predicts functional activation of the fear extinction circuit.
Resting amygdala and medial prefrontal metabolism predicts functional activation of the fear extinction circuit.
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DOI：
10.1176/appi.ajp.2011.10121780
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发表时间：
2012-04
期刊：
影响因子：
--
通讯作者：
Milad MR
中科院分区：
文献类型：
--
作者：
Linnman C;Zeidan MA;Furtak SC;Pitman RK;Quirk GJ;Milad MR
控制恐惧的能力的个体差异与背侧前扣带皮层、腹内侧前额叶皮层和杏仁核的激活有关。这项研究调查了是否可以预测在这些相同的区域的静息代谢在这个网络中的功能变化。使用[18F]-脱氧葡萄糖用正电子发射断层扫描研究健康受试者志愿者，以测量静息脑代谢。随后在功能性磁共振成像扫描仪中进行为期两天的恐惧条件反射和消退训练范例，以测量恐惧消退及其回忆过程中的大脑激活。皮肤电反应被用来作为条件反应的指标。杏仁核、背侧前扣带皮层和腹内侧前额叶皮层的静息代谢被用来预测恐惧消退和消退回忆的反应。在消退训练中，杏仁核的静息代谢对腹内侧前额叶皮质的激活有正向预测作用，对背侧前扣带回皮质的激活有负向预测作用。与此相反，在灭绝回忆，杏仁核代谢的休息负预测腹内侧前额叶皮层，积极预测背侧前扣带皮层，激活。静息背侧前扣带皮层代谢预测恐惧表达（皮肤电导反应）在灭绝回忆。静息状态下的脑代谢预测与恐惧消退记忆回忆相关的神经元反应性和皮肤电导变化。
Individual differences in ability to control fear have been linked to activation of dorsal anterior cingulate cortex, ventromedial prefrontal cortex, and amygdala. This study investigated whether functional variance in this network can be predicted by resting metabolism in these same regions. Healthy subject volunteers were studied with positron emission tomography using [18F]-deoxyglucose to measure resting brain metabolism. This was followed by a two-day fear conditioning and extinction training paradigm in a functional magnetic resonance imaging scanner to measure brain activation during fear extinction and its recall. Skin conductance response was used to index conditioned responding. Resting metabolism in amygdala, dorsal anterior cingulate cortex and ventromedial prefrontal cortex were used to predict responses during fear extinction and extinction recall. During extinction training, resting amygdala metabolism positively predicted ventromedial prefrontal cortex, and negatively predicted dorsal anterior cingulate cortex, activation. In contrast, during extinction recall, resting amygdala metabolism negatively predicted ventromedial prefrontal cortex, and positively predicted dorsal anterior cingulate cortex, activation. Resting dorsal anterior cingulate cortex metabolism predicted fear expression (skin conductance response) during extinction recall. Brain metabolism at rest predicts neuronal reactivity and skin conductance changes associated with recall of the fear extinction memory.
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DOI：
10.1523/jneurosci.2021-06.2006
发表时间：
2006-09-13
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Kalisch R;Korenfeld E;Stephan KE;Weiskopf N;Seymour B;Dolan RJ
通讯作者：
Dolan RJ
影响因子：
2.7
作者：
Berlau, Daniel J.;McGaugh, James L.
通讯作者：
McGaugh, James L.
DOI：
10.1523/jneurosci.2335-09.2009
发表时间：
2009-09-16
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Kim MJ;Whalen PJ
通讯作者：
Whalen PJ
影响因子：
82.9
作者：
Judenhofer, Martin S.;Wehrl, Hans F.;Pichler, Bernd J.
通讯作者：
Pichler, Bernd J.
影响因子：
6.9
作者：
Bryant, R. A.;Felmingham, K.;Williams, L.
通讯作者：
Williams, L.