Seven kinds of intermediate filament networks in the cytoplasm of polarized cells: structure and function.

Seven kinds of intermediate filament networks in the cytoplasm of polarized cells: structure and function.
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DOI:
10.1267/ahc.10009
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发表时间:
2010-05-01
影响因子:
2.4
通讯作者:
Suda M
Suda M
中科院分区:
生物学4区
文献类型:
--
作者:
Iwatsuki H;Suda M

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中间纤维参与细胞器的分布、信号转导、细胞极性和基因调控等重要生理功能。然而,关于执行这些功能的中频网络的结构的信息很少。我们已经阐明了在不同极化细胞的细胞质中存在七种IF网络:一个位于顶网正下方的顶点网络,一个位于细胞膜正下方的外周网络,一个围绕大量分泌颗粒的颗粒相关网络,一个围绕高尔基体的高尔基相关网络,一个位于核周区到细胞膜特定区域的放射状网络,一个围绕细胞核的双核网络,和一个完整的细胞质网络。在这篇综述中,我们描述了这七种IF网络,并讨论了它们的生物学作用。
Intermediate filaments (IFs) are involved in many important physiological functions, such as the distribution of organelles, signal transduction, cell polarity and gene regulation. However, little information exists on the structure of the IF networks performing these functions. We have clarified the existence of seven kinds of IF networks in the cytoplasm of diverse polarized cells: an apex network just under the terminal web, a peripheral network lying just beneath the cell membrane, a granule-associated network surrounding a mass of secretory granules, a Golgi-associated network surrounding the Golgi apparatus, a radial network locating from the perinuclear region to the specific area of the cell membrane, a juxtanuclear network surrounding the nucleus, and an entire cytoplasmic network. In this review, we describe these seven kinds of IF networks and discuss their biological roles.
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发表时间: 1994-03-01
影响因子: 4.1
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