Electrostatic catalysis of a click reaction in a microfluidic cell.
Electrostatic catalysis of a click reaction in a microfluidic cell.
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DOI：
10.1038/s41467-024-44716-2
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发表时间：
2024-01-26
影响因子：
16.6
通讯作者：
Puigmarti-Luis, Josep
中科院分区：
文献类型：
--
作者：
Sevim, Semih;Sanchis-Gual, Roger;Franco, Carlos;Aragones, Albert C.;Darwish, Nadim;Kim, Donghoon;Picca, Rosaria Anna;Nelson, Bradley J.;Ruiz, Eliseo;Pane, Salvador;Diez-Perez, Ismael;Puigmarti-Luis, Josep
电场在自然界的酶机制中被强调为智能试剂，因为它们可以直接触发或加速具有立体和区域特异性的化学过程。在酶催化中，化学物质的受控质量传递也是促进活性反应位点中反应物可用性的关键。然而，最近在开发从定向电场中获益的清洁催化方面的进展仅限于单分子水平的理论和实验研究，其中无法测试对质量传输和可扩展性的控制。在这里，我们量化了一个典型的Huisgen环加成在大面积电极表面的静电催化，并直接比较其性能与传统的Cu（I）催化。我们定制的微流控池增强了试剂向带电反应界面的传输。这种连续流微流体静电反应器是电场驱动平台的一个例子，在该平台上可以有效地实施和调节清洁的大规模静电催化过程。我们能否利用电场（EF）作为智能试剂来催化化学过程？在这里，作者开发了一种连续流静电反应器作为微流体平台，其允许在利用电压控制的EF作为唯一催化剂的大电极表面上有效催化点击反应。
Electric fields have been highlighted as a smart reagent in nature’s enzymatic machinery, as they can directly trigger or accelerate chemical processes with stereo- and regio-specificity. In enzymatic catalysis, controlled mass transport of chemical species is also key in facilitating the availability of reactants in the active reaction site. However, recent progress in developing a clean catalysis that profits from oriented electric fields is limited to theoretical and experimental studies at the single molecule level, where both the control over mass transport and scalability cannot be tested. Here, we quantify the electrostatic catalysis of a prototypical Huisgen cycloaddition in a large-area electrode surface and directly compare its performance to the conventional Cu(I) catalysis. Our custom-built microfluidic cell enhances reagent transport towards the electrified reactive interface. This continuous-flow microfluidic electrostatic reactor is an example of an electric-field driven platform where clean large-scale electrostatic catalytic processes can be efficiently implemented and regulated. Can we utilize electric fields (EF) as a smart reagent to catalyze chemical processes? Here the authors develop a continuous-flow electrostatic reactor as a microfluidic platform that allows for the effective catalysis of click reaction over a large electrode surface exploiting voltage-controlled EF as the sole catalyst.
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影响因子：
64.5
作者：
López-Otín C;Blasco MA;Partridge L;Serrano M;Kroemer G
通讯作者：
Kroemer G
影响因子：
41.2
作者：
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影响因子：
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作者：
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作者：
Rojas-Vázquez S;Blasco-Chamarro L;López-Fabuel I;Martínez-Máñez R;Fariñas I
通讯作者：
Fariñas I
衰老肺和疾病的细胞衰老。
影响因子：
6
作者：
Aghali, Arbi;Ngassie, Maunick Lefin Koloko;Pabelick, Christina M.;Prakash, Y. S.
通讯作者：
Prakash, Y. S.