Chronic Exposure to Dim Light at Night or Irregular Lighting Conditions Impact Circadian Behavior, Motor Coordination, and Neuronal Morphology.
Chronic Exposure to Dim Light at Night or Irregular Lighting Conditions Impact Circadian Behavior, Motor Coordination, and Neuronal Morphology.
复制标题
夜间长期暴露在暗光或不规则的光照条件下，会影响昼夜行为、运动协调和神经元形态。
DOI：
10.3389/fnins.2022.855154
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发表时间：
2022
影响因子：
4.3
通讯作者：
Banks, Gareth T.
中科院分区：
文献类型：
--
作者：
Delorme, Tara C.;Srikanta, Shashank B.;Fisk, Angus S.;Cloutier, Marie-Eve;Sato, Miho;Pothecary, Carina A.;Merz, Chantal;Foster, Russell G.;Brown, Steven A.;Peirson, Stuart N.;Cermakian, Nicolas;Banks, Gareth T.
不合时宜的光照已被证明会对生理和行为的多个方面产生负面影响。在这里，我们分析了长期暴露在异常光照条件下对小鼠的影响。我们让小鼠在一年的时间里接受以下任一种情况：标准的明/暗周期，即在昼夜周期的暗相中存在低水平光的“光污染”条件，或者是工作日和周末光相长度相差6小时的变化光周期(“社会时差”)。小鼠表现出几种昼夜节律活动表型，以及运动功能的变化，特别是与DLAN条件有关。我们的数据表明，这些表型可能是由于核心时钟之外的变化造成的。其他脑区的树突变化增加了这些表型是由时钟外神经元协调变化所调节的可能性。鉴于人工光暴露在现代世界中的普遍存在，需要进一步的工作来确定这些负面影响是否也在人类身上观察到。
Mistimed exposure to light has been demonstrated to negatively affect multiple aspects of physiology and behavior. Here we analyzed the effects of chronic exposure to abnormal lighting conditions in mice. We exposed mice for 1 year to either: a standard light/dark cycle, a “light-pollution” condition in which low levels of light were present in the dark phase of the circadian cycle (dim light at night, DLAN), or altered light cycles in which the length of the weekday and weekend light phase differed by 6 h (“social jetlag”). Mice exhibited several circadian activity phenotypes, as well as changes in motor function, associated particularly with the DLAN condition. Our data suggest that these phenotypes might be due to changes outside the core clock. Dendritic spine changes in other brain regions raise the possibility that these phenotypes are mediated by changes in neuronal coordination outside of the clock. Given the prevalence of artificial light exposure in the modern world, further work is required to establish whether these negative effects are observed in humans as well.
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握力强度可能是小鼠与年龄相关的早期指标。
DOI：
10.3402/pba.v6.32981
发表时间：
2016
期刊：
Pathobiology of aging & age related diseases
影响因子：
--
作者：
Ge X;Cho A;Ciol MA;Pettan-Brewer C;Snyder J;Rabinovitch P;Ladiges W
通讯作者：
Ladiges W
影响因子：
2.7
作者：
Chen R;Weitzner AS;McKennon LA;Fonken LK
通讯作者：
Fonken LK
影响因子：
56.9
作者：
CZEISLER, CA;ALLAN, JS;KRONAUER, RE
通讯作者：
KRONAUER, RE
DOI：
10.4049/jimmunol.1001026
发表时间：
2010-11-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Castanon-Cervantes O;Wu M;Ehlen JC;Paul K;Gamble KL;Johnson RL;Besing RC;Menaker M;Gewirtz AT;Davidson AJ
通讯作者：
Davidson AJ
影响因子：
11
作者：
Banks G;Lassi G;Hoerder-Suabedissen A;Tinarelli F;Simon MM;Wilcox A;Lau P;Lawson TN;Johnson S;Rutman A;Sweeting M;Chesham JE;Barnard AR;Horner N;Westerberg H;Smith LB;Molnár Z;Hastings MH;Hirst RA;Tucci V;Nolan PM
通讯作者：
Nolan PM