Light at night during development in mice has modest effects on adulthood behavior and neuroimmune activation.
Light at night during development in mice has modest effects on adulthood behavior and neuroimmune activation.
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DOI：
10.1016/j.bbr.2021.113171
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发表时间：
2021-05-07
影响因子：
2.7
通讯作者：
Fonken LK
中科院分区：
文献类型：
--
作者：
Chen R;Weitzner AS;McKennon LA;Fonken LK
夜间暴露于光（LAN）会破坏昼夜节律系统，从而改变神经免疫反应和相关行为。接触LAN的增加会影响所有年龄段的人-并且可能在早期和青春期产生特别有害的影响。尽管如此，大多数关于LAN的行为和生理影响的研究都是在成年动物中进行的。在这里，我们评估了在关键的发育窗口期对成年神经免疫功能和情感/疾病行为的影响。雄性和雌性C57 BL/6 J小鼠在生命早期（PND 10 -24）或青春期（PND 30 -44）[对照：12：12光照（150 lx）/黑暗（0 lx）循环]暴露于昏暗LAN [12：12光照（150 lx）/昏暗（15 lx）循环]。在幼年期（PND 42-44）和成年期（PND 60）评估行为。与我们的假设相反，暴露于昏暗LAN的幼年小鼠没有表现出焦虑或抑郁样行为的变化。到成年时，青少年LAN暴露的雌性小鼠在一项行为任务中表现出适度的焦虑样表型，但在另一项行为任务中则没有。青少年LAN暴露也诱导抑郁样行为在强迫游泳任务在成年期的雄性和雌性小鼠。此外，发育性LAN加剧了雌性小鼠而非雄性小鼠外周LPS后的海马细胞因子反应（IL-1β）。这些结果表明，雌性小鼠可能比雄性小鼠更容易受到发育性LAN的影响：LAN雌性小鼠在成年期具有适度的焦虑样表型，并且在LPS攻击后，海马IL-1β表达较高。总之，小鼠发育中的LAN暴露促进了对焦虑和抑郁样症状的易感性的适度增加。
Exposure to light at night (LAN) can disrupt the circadian system, thereby altering neuroimmune reactivity and related behavior. Increased exposure to LAN affects people of all ages – and could have particularly detrimental effects during early-life and adolescence. Despite this, most research on the behavioral and physiological effects of LAN has been conducted in adult animals. Here we evaluated the effects of dim LAN during critical developmental windows on adulthood neuroimmune function and affective/sickness behaviors. Male and female C57BL/6 J mice were exposed to dim LAN [12:12 light (150 lx)/dim (15 lx) cycle] during early life (PND10–24) or adolescence (PND30–44) [control: 12:12 light (150 lx)/dark (0 lx) cycle]. Behaviors were assessed during juvenile (PND 42–44) and adult (PND60) periods. Contrary to our hypothesis, juvenile mice that were exposed to dim LAN did not exhibit changes in anxiety- or depressive-like behaviors. By adulthood, adolescent LAN-exposed female mice showed a modest anxiety-like phenotype in one behavioral task but not another. Adolescent LAN exposure also induced depressive-like behavior in a forced swim task in adulthood in both male and female mice. Additionally, developmental LAN exacerbated the hippocampal cytokine response (IL-1β) following peripheral LPS in female, but not male mice. These results suggest female mice may be more susceptible to developmental LAN than male mice: LAN female mice had a modest anxiety-like phenotype in adulthood, and upon LPS challenge, higher hippocampal IL-1β expression. Taken together, developmental LAN exposure in mice promotes a modest increase in susceptibility to anxiety- and depressive-like symptoms.
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影响因子：
4.6
作者：
Biesmans S;Meert TF;Bouwknecht JA;Acton PD;Davoodi N;De Haes P;Kuijlaars J;Langlois X;Matthews LJ;Ver Donck L;Hellings N;Nuydens R
通讯作者：
Nuydens R
影响因子：
6.3
作者：
Bara, Ana-Claudia;Arber, Sara
通讯作者：
Arber, Sara
DOI：
10.1073/pnas.93.4.1619
发表时间：
1996-02-20
影响因子：
11.1
作者：
Coplan, JD;Andrews, MW;Nemeroff, CB
通讯作者：
Nemeroff, CB
影响因子：
3.5
作者：
Barha, Cindy K.;Brummelte, Susanne;Galea, Liisa A. M.
通讯作者：
Galea, Liisa A. M.
影响因子：
3
作者：
Bilbo SD;Schwarz JM
通讯作者：
Schwarz JM