Anemia during SARS-CoV-2 infection is associated with rehospitalization after viral clearance.
Anemia during SARS-CoV-2 infection is associated with rehospitalization after viral clearance.
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DOI：
10.1016/j.isci.2021.102780
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发表时间：
2021-07-23
期刊：
影响因子：
5.8
通讯作者：
Soundararajan V
中科院分区：
文献类型：
--
作者：
Lenehan PJ;Ramudu E;Venkatakrishnan AJ;Berner G;McMurry R;O'Horo JC;Badley AD;Morice W 2nd;Halamka J;Soundararajan V
COVID-19患者在病毒清除后可能会出现症状和并发症。确定可能经历这些长期影响的患者的临床特征是很重要的。我们进行了一项回顾性研究，比较pcr证实的SARS-CoV-2清除后再住院的患者（n = 104）和病毒清除后未再住院的患者（n = 278）的纵向实验室测试测量（血红蛋白、红细胞压积、肾小球滤过率、血清肌酐和血尿素氮）。再住院患者在COVID-19诊断前一年（Cohen’s D = - 0.50; p = 1.2 × 10−3）和SARS-CoV-2活动性感染期间（Cohen’s D = - 0.71; p = 4.6 × 10−8）血红蛋白水平中位数较低。再次住院的患者在活动性感染期间也更容易被诊断为中度或重度贫血（优势比= 4.07;p = 4.99 × 10−9）。这些发现表明，在COVID-19患者的风险分层算法中应考虑贫血相关的实验室检查。清除SARS-CoV-2后再入院患者的实验室检测特征明显，再入院患者在感染SARS-CoV-2前和感染期间血红蛋白较低，再入院患者在活动性感染期间更容易出现贫血；病理生理学
Patients with COVID-19 can experience symptoms and complications after viral clearance. It is important to identify clinical features of patients who are likely to experience these prolonged effects. We conducted a retrospective study to compare longitudinal laboratory test measurements (hemoglobin, hematocrit, estimated glomerular filtration rate, serum creatinine, and blood urea nitrogen) in patients rehospitalized after PCR-confirmed SARS-CoV-2 clearance (n = 104) versus patients not rehospitalized after viral clearance (n = 278). Rehospitalized patients had lower median hemoglobin levels in the year prior to COVID-19 diagnosis (Cohen's D = −0.50; p = 1.2 × 10−3) and during their active SARS-CoV-2 infection (Cohen's D = −0.71; p = 4.6 × 10−8). Rehospitalized patients were also more likely to be diagnosed with moderate or severe anemia during their active infection (Odds Ratio = 4.07; p = 4.99 × 10−9). These findings suggest that anemia-related laboratory tests should be considered in risk stratification algorithms for patients with COVID-19. Patients rehospitalized after SARS-CoV-2 clearance have distinct laboratory test profiles Rehospitalized patients have lower hemoglobin before and during SARS-CoV-2 infection Rehospitalized patients are more likely to experience anemia during active infection Virology; Pathophysiology
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DOI：
10.1016/j.ajem.2021.03.083
发表时间：
2021-10
期刊：
The American journal of emergency medicine
影响因子：
--
作者：
Oh SM;Skendelas JP;Macdonald E;Bergamini M;Goel S;Choi J;Segal KR;Vivek K;Nair S;Leff J
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影响因子：
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Conlon N
影响因子：
64.8
作者：
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影响因子：
7.1
作者：
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COVID-19与19号相关的急性肾脏损伤：第25次急性疾病质量倡议（ADQI）工作组的共识报告。
DOI：
10.1038/s41581-020-00356-5
发表时间：
2020-12
期刊：
Nature reviews. Nephrology
影响因子：
--
作者：
Nadim MK;Forni LG;Mehta RL;Connor MJ Jr;Liu KD;Ostermann M;Rimmelé T;Zarbock A;Bell S;Bihorac A;Cantaluppi V;Hoste E;Husain-Syed F;Germain MJ;Goldstein SL;Gupta S;Joannidis M;Kashani K;Koyner JL;Legrand M;Lumlertgul N;Mohan S;Pannu N;Peng Z;Perez-Fernandez XL;Pickkers P;Prowle J;Reis T;Srisawat N;Tolwani A;Vijayan A;Villa G;Yang L;Ronco C;Kellum JA
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