A potential role for the paraventricular nucleus of the thalamus in mediating individual variation in Pavlovian conditioned responses.
A potential role for the paraventricular nucleus of the thalamus in mediating individual variation in Pavlovian conditioned responses.
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丘脑的旁去室核的潜在作用在介导帕夫洛夫条件反应中的个体变异中。
DOI：
10.3389/fnbeh.2014.00079
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发表时间：
2014
影响因子：
3
通讯作者：
Flagel SB
中科院分区：
文献类型：
--
作者：
Haight JL;Flagel SB
有充分的证据表明，丘脑室旁核(PVT)参与线索奖赏学习，特别是当它与寻求毒品行为有关时。然而，它在这些复杂过程中的确切作用仍不清楚。在这里，我们将介绍和讨论来自我们自己的实验室的数据，这些数据表明PVT在多种形式的刺激-奖赏学习中发挥作用，并通过不同的神经生物学系统做到这一点。利用捕捉个体对奖赏相关线索反应的动物模型，我们能够从奖赏线索的预测性属性中解析出动机，并阐明这些不同形式的线索-奖赏学习背后的神经回路。当大鼠接触到经典的巴甫洛夫条件反射范式，其中一个线索预测食物奖励时，一些被称为符号追踪器的大鼠接近并操纵呈现的线索。这一行为表明将激励显著归因于线索。也就是说，提示获得了对手势跟踪器行为的过度控制。相比之下，其他被称为目标追踪器的大鼠，将线索视为一个纯粹的预测因素，并在其呈现时进入奖励传递的位置。基于我们自己利用这个模型的数据，我们假设PVT代表一个共同的节点，但对符号和目标跟踪反应进行不同的调节。我们推测，PVT通过皮层下的多巴胺依赖机制来调节信号跟踪行为，或激励显著的归因。相反，我们认为目标跟踪行为，或预测值的归因，是前脑皮质(PRL)和PVT之间“自上而下”谷氨酸能处理的产物。总之，来自我们实验室和其他实验室的数据支持PVT在线索动机行为中的作用，并表明它可能是神经电路中在成瘾和相关障碍中出错的一个重要部位。
There is ample evidence to suggest that the paraventricular nucleus of the thalamus (PVT) mediates cue-reward learning, especially as it relates to drug-seeking behavior. However, its exact role in these complex processes remains unknown. Here we will present and discuss data from our own laboratory which suggests that the PVT plays a role in multiple forms of stimulus-reward learning, and does so via distinct neurobiological systems. Using an animal model that captures individual variation in response to reward-associated cues, we are able to parse the incentive from the predictive properties of reward cues and to elucidate the neural circuitry underlying these different forms of cue-reward learning. When rats are exposed to a classical Pavlovian conditioning paradigm, wherein a cue predicts food reward, some rats, termed sign-trackers, approach and manipulate the cue upon its presentation. This behavior is indicative of attributing incentive salience to the cue. That is, the cue gains excessive control over behavior for sign-trackers. In contrast, other rats, termed goal-trackers, treat the cue as a mere predictor, and upon its presentation go to the location of reward delivery. Based on our own data utilizing this model, we hypothesize that the PVT represents a common node, but differentially regulates the sign- vs. goal-tracking response. We postulate that the PVT regulates sign-tracking behavior, or the attribution of incentive salience, via subcortical, dopamine-dependent mechanisms. In contrast, we propose that goal-tracking behavior, or the attribution of predictive value, is the product of “top-down” glutamatergic processing between the prelimbic cortex (PrL) and the PVT. Together, data from our laboratory and others support a role for the PVT in cue-motivated behaviors and suggest that it may be an important locus within the neural circuitry that goes awry in addiction and related disorders.
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影响因子：
3.3
作者：
Choi, D. L.;Davis, J. F.;Magrisso, I. J.;Fitzgerald, M. E.;Lipton, J. W.;Benoit, S. C.
通讯作者：
Benoit, S. C.
与奖励相关行为中的多巴胺信号传导。
影响因子：
3.5
作者：
Baik JH
通讯作者：
Baik JH
影响因子：
4.2
作者：
Browning, Jenny R.;Jansen, Heiko T.;Sorg, Barbara A.
通讯作者：
Sorg, Barbara A.
影响因子：
64.8
作者：
Flagel SB;Clark JJ;Robinson TE;Mayo L;Czuj A;Willuhn I;Akers CA;Clinton SM;Phillips PE;Akil H
通讯作者：
Akil H
影响因子：
56.9
作者：
COOPER, RM;TAYLOR, LH
通讯作者：
TAYLOR, LH