On vasa vasorum: A history of advances in understanding the vessels of vessels.
On vasa vasorum: A history of advances in understanding the vessels of vessels.
复制标题
关于血管：了解血管的血管进展的历史。
DOI：
10.1126/sciadv.abl6364
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发表时间：
2022-04-22
期刊：
影响因子：
13.6
通讯作者：
中科院分区：
文献类型：
--
作者：
血管是一个重要的微血管网，支持大血管的外壁。尽管这些动态微血管已经研究了几个世纪，但它们在血管健康和疾病中的重要性和影响尚未完全认识到。现在有丰富的知识，关于什么样的本地祖细胞群体组成和同居的vasa vasorum和他们如何可能有助于生理和病理变化的网络或其扩张通过血管生成或血管生成。血管重塑是否引发或控制疾病进展或是否是心血管病理的结果的证据仍然有限。血管成像在了解心血管疾病严重程度和病理生理学方面的最新进展为治疗诊断打开了大门。努力控制血管生成和血管发生的方法可减轻血管介导的心血管疾病和涉及微循环的新发疾病。几个世纪以来的进展突出了血管在心血管疾病中的重要性。
The vasa vasorum are a vital microvascular network supporting the outer wall of larger blood vessels. Although these dynamic microvessels have been studied for centuries, the importance and impact of their functions in vascular health and disease are not yet fully realized. There is now rich knowledge regarding what local progenitor cell populations comprise and cohabitate with the vasa vasorum and how they might contribute to physiological and pathological changes in the network or its expansion via angiogenesis or vasculogenesis. Evidence of whether vasa vasorum remodeling incites or governs disease progression or is a consequence of cardiovascular pathologies remains limited. Recent advances in vasa vasorum imaging for understanding cardiovascular disease severity and pathophysiology open the door for theranostic opportunities. Approaches that strive to control angiogenesis and vasculogenesis potentiate mitigation of vasa vasorum–mediated contributions to cardiovascular diseases and emerging diseases involving the microcirculation. Advances over the centuries highlight the importance of vasa vasorum in cardiovascular disease.
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影响因子：
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DOI：
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