Subthalamic nucleus discharge patterns during movement in the normal monkey and Parkinsonian patient.
Subthalamic nucleus discharge patterns during movement in the normal monkey and Parkinsonian patient.
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DOI：
10.1016/j.brainres.2008.12.062
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发表时间：
2009-03-13
期刊：
影响因子：
2.9
通讯作者：
Eskandar EN
中科院分区：
文献类型：
--
作者：
Gale JT;Shields DC;Jain FA;Amirnovin R;Eskandar EN
帕金森病（PD）的病理生理学特征是基底神经节（BG）神经元的放电频率、爆发模式和振荡活动的紊乱。在这项研究中，丘脑底核（FDN）神经元的活动模式在人类与PD进行了比较，在正常猴子在类似的意志运动的性能。当PD患者和动物在监视器上显示的目标方向上移动操纵杆时，收集单单位的记录。当比较所有PD人和正常猴神经元的放电率时，未观察到显著差异。然而，当神经元按运动反应类型分类时（即，兴奋、抑制或对运动无反应）的统计学差异-在PD兴奋神经元中最显著。爆发活动分析表明，与猴相比，PD人的爆发间和爆发内活动更大，与神经元反应类型无关。此外，同时记录的神经元在人类表现出一致的振荡同步在有限的频带，而在猴子同步振荡神经元不限于不同的频率。在运动过程中，放电和爆发率呈正相关，独立于受试者或神经元的反应类型，然而，率和振荡活动更强烈的PD人类比正常猴相关。有趣的是，在所有分析领域中，与正常猴脑中的海马神经元相比，PD中的海马神经元表现出降低的反应变异性。因此，PD的净效应可能是BG神经元的生理自由度降低，信息承载能力降低。
The pathophysiology of Parkinson disease (PD) is characterized by derangements in the discharge rates, bursting patterns, and oscillatory activity of basal ganglia (BG) neurons. In this study, subthalamic nucleus (STN) neuronal activity patterns in humans with PD was compared with that in the normal monkey during performance of similar volitional movements. Single-unit STN recordings were collected while PD patients and animals moved a joystick in the direction of targets presented on a monitor. When discharge rates in all PD human and normal monkey neurons were compared, no significant differences were observed. However, when neurons were classified by peri-movement response type (i.e., excited, inhibited, or unresponsive to movement) statistical differences were demonstrated – most significantly among PD excited neurons. Analysis of burst activity demonstrated inter- and intra-burst activities were greater in the PD human compared to the monkey irrespective of neuronal response type. Moreover, simultaneously recorded neurons in the human demonstrated consistent oscillatory synchronization at restricted frequency bands, whereas synchronized oscillatory neurons in the monkey were not restricted to distinct frequencies. During movement, discharge and burst rates were positively correlated, independent of subject or neuronal response type; however, rates and oscillatory activity were more strongly correlated in the PD human than the normal monkey. Interestingly, across all domains of analysis, STN neurons in PD demonstrated reduced response variability when compared to STN neurons in the normal monkey brain. Thus, the net effect of PD may be a reduction in the physiological degrees of freedom of BG neurons with diminished information carrying capacity.
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