Interactions between two propagating waves in rat visual cortex.
Interactions between two propagating waves in rat visual cortex.
复制标题
DOI：
10.1016/j.neuroscience.2012.04.062
复制
发表时间：
2012-08-02
期刊：
影响因子：
3.3
通讯作者：
Wu, J. -Y.
中科院分区：
文献类型：
--
作者：
Gao, X.;Xu, W.;Wang, Z.;Takagaki, K.;Li, B.;Wu, J. -Y.
感觉诱发的传播波在感觉皮层中经常被观察到。然而，一个诱发的传播波如何影响随后的感觉输入所引起的活动，或者当两个传播波被同时的感觉输入唤起时如何相互作用，在很大程度上是未知的。利用电压敏感染料成像技术，我们研究了大鼠视皮层中两个诱发波之间的相互作用，以及由于波与波相互作用而引起的神经元群体中去极化的时空模式。我们已经发现，视觉诱发的传播波有大约300ms的不应期，在这段时间内，对后续视觉刺激的反应被抑制。在不同位置同时呈现两个视觉刺激可以引起相互传播的两个波，这两个波融合在一起。融合显著缩短了反应的潜伏期和半宽度，导致了诱发种群活动的空间分布的变化。视觉诱发的传播波也可以被先前的自发波抑制。传播波后的不应期和两波之间的融合可能通过改变感觉事件引起的群体神经元活动的时空轮廓而有助于视觉感觉加工。
Sensory-evoked propagating waves are frequently observed in sensory cortex. However, it is largely unknown how an evoked propagating wave affects the activity evoked by subsequent sensory inputs, or how two propagating waves interact when evoked by simultaneous sensory inputs. Using voltage-sensitive dye imaging, we investigated the interactions between two evoked waves in rat visual cortex, and the spatiotemporal patterns of depolarization in the neuronal population due to wave-to-wave interactions. We have found that visually-evoked propagating waves have a refractory period of about 300 ms, within which the response to a subsequent visual stimulus is suppressed. Simultaneous presentation of two visual stimuli at different locations can evoke two waves propagating toward each other, and these two waves fuse. Fusion significantly shortens the latency and half-width of the response, leading to changes in the spatial profile of evoked population activity. The visually-evoked propagating wave may also be suppressed by a preceding spontaneous wave. The refractory period following a propagating wave and the fusion between two waves may contribute to visual sensory processing by modifying the spatiotemporal profile of population neuronal activity evoked by sensory events.
登录
查看更多内容
影响因子：
16.2
作者：
Han, Feng;Caporale, Natalia;Dan, Yang
通讯作者：
Dan, Yang
影响因子：
16.2
作者：
Ferezou, Isabelle;Haiss, Florent;Petersen, Carl C. H.
通讯作者：
Petersen, Carl C. H.
影响因子：
5.5
作者：
Contreras, D;Timofeev, I;Steriade, M
通讯作者：
Steriade, M
影响因子：
5.5
作者：
Jancke, D;Erlhagen, W;Dinse, HR
通讯作者：
Dinse, HR
影响因子：
5.3
作者：
Huang, XY;Troy, WC;Wu, JY
通讯作者：
Wu, JY