Is depression more likely following childbirth? A population-based study.
Is depression more likely following childbirth? A population-based study.
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DOI：
10.1007/s00737-018-0891-5
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发表时间：
2019-04
期刊：
影响因子：
--
通讯作者：
Sandin S
中科院分区：
文献类型：
--
作者：
Silverman ME;Reichenberg A;Lichtenstein P;Sandin S
产后抑郁症（PPD）是一种以分娩为条件的抑郁发作。我们检查了分娩后抑郁的风险是否比随机生成的与分娩无关的时间更高。在一项对1997-2008年瑞典所有活产单胎妇女的前瞻性队列研究中，我们首先计算了有抑郁史的母亲与没有抑郁史的母亲患产后抑郁症的相对风险（RR）。接下来，我们重复了计算，但现在是在电脑生成任意的“幻影分娩”日期之后，与真实分娩日期无关。对于这个虚幻的分娩日期，我们使用了所有同龄女性的平均预期分娩日期。为了对每一组进行分析，研究人员对女性进行了整整一年的跟踪调查。拟合泊松回归，计算RR和双侧95%置信区间（CI）。在707,701例分娩中，有4,397例PPD病例和4,687例对照抑郁症病例。PPD的RR为21.0 （CI: 19.7 ~ 22.4）。对照组抑郁的RR为26.2 （CI: 24.7 ~ 27.9）。我们提供的证据表明，分娩后PPD的风险并不比与分娩无关的随机日期更大。这一发现表明，产后时期可能并不一定代表临床显著抑郁的高度易感性时期，并且对抑郁症与分娩共变的良好观察并不一定等同于因果关系，而可能是产后妇女代表医学上捕捉到的人群的次要影响。
Postpartum depression (PPD) is characterized as a depressive episode conditional on childbirth. We examined whether the risk of depression is higher following childbirth than a randomly generated time unrelated to childbirth. In a prospective cohort of all women with live singleton births in Sweden, 1997–2008, we first calculated the relative risk (RR) of PPD for mothers with a history of depression compared to mothers without such a history. Next we repeated the calculations, but now for depression following a computer generated arbitrary “phantom delivery” date, unrelated to the true date of delivery. For this phantom delivery date, we used the average expected date of delivery for all women of the same age. For the analyses of each group, women were followed for a full calendar year. We fitted Poisson regression and calculated RR and two-sided 95% confidence intervals (CI). Among a total of 707,701 deliveries, there were 4,397 PPD cases and 4,687 control depression cases. The RR of PPD was 21.0 (CI: 19.7–22.4). The RR of depression in the control group was 26.2 (CI: 24.7–27.9). We provide evidence that the risk for PPD is no greater following childbirth than following a random date unrelated to childbirth. This finding suggests that the postpartum period may not necessarily represent a time of heightened vulnerability for clinically significant depression and that the well established observation of depression covarying with childbirth does not necessarily equate to causation, but rather may be a secondary effect of postpartum women representing a medically captured population.
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影响因子：
9.8
作者：
Guardino CM;Schetter CD
通讯作者：
Schetter CD
DOI：
10.1146/annurev-clinpsy-050212-185612
发表时间：
2013-01-01
期刊：
ANNUAL REVIEW OF CLINICAL PSYCHOLOGY, VOL 9
影响因子：
--
作者：
O'Hara, Michael W.;McCabe, Jennifer E.
通讯作者：
McCabe, Jennifer E.
DOI：
10.4088/jcp.12m07693
发表时间：
2012-12-01
期刊：
The Journal of clinical psychiatry
影响因子：
--
作者：
Altemus, Margaret;Neeb, Christine C;Bleiberg, Kathryn L
通讯作者：
Bleiberg, Kathryn L
影响因子：
7.4
作者：
Hoertel, Nicolas;Lopez, Saioa;Peyre, Hugo;Wall, Melanie M.;Gonzalez-Pinto, Ana;Limosin, Frederic;Blanco, Carlos
通讯作者：
Blanco, Carlos
影响因子：
105.7
作者：
Klein, JG
通讯作者：
Klein, JG