Impact of Fluoxetine on Behavioral Invigoration of Appetitive and Aversively Motivated Responses: Interaction With Dopamine Depletion.
Impact of Fluoxetine on Behavioral Invigoration of Appetitive and Aversively Motivated Responses: Interaction With Dopamine Depletion.
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DOI：
10.3389/fnbeh.2021.700182
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发表时间：
2021
影响因子：
3
通讯作者：
Correa M
中科院分区：
文献类型：
--
作者：
Carratalá-Ros C;López-Cruz L;Martínez-Verdú A;Olivares-García R;Salamone JD;Correa M
行为激活受损和与努力相关的动机功能障碍（如疲劳和无力）正在使抑郁症的难治性症状变得虚弱。抑郁症患者倾向于选择低强度活动。为了确定广泛使用的抗抑郁药氟西汀是否可以改善行为激活并逆转多巴胺 (DA) 耗竭引起的无力感，对雄性 CD1 小鼠在厌恶环境下的剧烈逃避行为（强迫游泳测试，FST）以及运动偏好选择任务 [跑轮 (RW)-T 迷宫选择任务] 进行了评估。在 FST 中，氟西汀增加了主动行为（游泳、攀爬），同时减少了被动行为（不动）。然而，氟西汀不能有效减少 DA 消耗剂丁苯那嗪引起的无力感，从而进一步减少剧烈攀爬和增加不动性。在 T 迷宫中，单独使用氟西汀会产生与丁苯那嗪相同的效果。此外，氟西汀并没有逆转丁苯那嗪引起的RW时间抑制，但它减少了蔗糖摄入持续时间。氟西汀在 DA 耗尽的小鼠中产生的这种作用模式与通过预喂或使食物变苦来降低食物强化的作用不同，因为在这两种情况下，蔗糖摄入时间都减少了，但动物通过增加 RW 时间来补偿。因此，氟西汀改善了厌恶环境中的逃避，但降低了对主动强化的相对偏好。此外，氟西汀并不能逆转 DA 消耗的无反应效应。这些结果对于使用氟西汀治疗抑郁症患者的动力症状（例如无力）具有影响。
Impaired behavioral activation and effort-related motivational dysfunctions like fatigue and anergia are debilitating treatment-resistant symptoms of depression. Depressed people show a bias towards the selection of low effort activities. To determine if the broadly used antidepressant fluoxetine can improve behavioral activation and reverse dopamine (DA) depletion-induced anergia, male CD1 mice were evaluated for vigorous escape behaviors in an aversive context (forced swim test, FST), and also with an exercise preference choice task [running wheel (RW)-T-maze choice task]. In the FST, fluoxetine increased active behaviors (swimming, climbing) while reducing passive ones (immobility). However, fluoxetine was not effective at reducing anergia induced by the DA-depleting agent tetrabenazine, further decreasing vigorous climbing and increasing immobility. In the T-maze, fluoxetine alone produced the same pattern of effects as tetrabenazine. Moreover, fluoxetine did not reverse tetrabenazine-induced suppression of RW time but it reduced sucrose intake duration. This pattern of effects produced by fluoxetine in DA-depleted mice was dissimilar from devaluing food reinforcement by pre-feeding or making the food bitter since in both cases sucrose intake time was reduced but animals compensated by increasing time in the RW. Thus, fluoxetine improved escape in an aversive context but decreased relative preference for active reinforcement. Moreover, fluoxetine did not reverse the anergic effects of DA depletion. These results have implications for the use of fluoxetine for treating motivational symptoms such as anergia in depressed patients.
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DOI：
10.1111/j.1440-1681.1995.tb01947.x
发表时间：
1995-11-01
影响因子：
2.9
作者：
CAMERON, DL;WILLIAMS, JT
通讯作者：
WILLIAMS, JT
影响因子：
2.6
作者：
Frank S
通讯作者：
Frank S
影响因子：
3.4
作者：
Carr, Gregory V.;Lucki, Irwin
通讯作者：
Lucki, Irwin
影响因子：
3.8
作者：
Di Mascio, M;Di Giovanni, G;Esposito, E
通讯作者：
Esposito, E
影响因子：
3
作者：
Carratala-Ros, Carla;Lopez-Cruz, Laura;Correa, Merce
通讯作者：
Correa, Merce