The protein interaction networks of mucolipins and two-pore channels.
The protein interaction networks of mucolipins and two-pore channels.
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DOI：
10.1016/j.bbamcr.2018.10.020
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发表时间：
2019-07
期刊：
影响因子：
--
通讯作者：
Grimm C
中科院分区：
文献类型：
--
作者：
Krogsaeter EK;Biel M;Wahl-Schott C;Grimm C
内溶酶体、非选择性阳离子通道、双孔通道（TPC）和粘脂（TRPML）调节细胞内膜动力学和自噬。虽然部分相互补偿，异构体特异性的细胞内分布，细胞类型的表达模式，和调节机制表明不同的通道异构体赋予不同的性质的细胞。简要地说，建立TPC/TRPML功能和相互作用的合作伙伴（“interactomes”）进行了讨论。新型TRPML 3相互作用，实验获得的通道相互作用进行荟萃分析。因此，相互作用组被比较和对比，并且随后针对TPC 1、TPC 2、TRPML 1和TRPML 3进行详细描述。TPC相互作用组是明确定义的，包括细胞内膜组织蛋白。TRPML相互作用组是多种多样的，包括心肌收缩和伴侣介导的自噬蛋白，以及细胞间信号传导的调节剂。包括最近提出的治疗癌症，感染，代谢疾病和神经退行性疾病的目标，TPC/TRPML理解的进步是相当重要的。这篇综述提出了阐明TPC/TRPML与健康和疾病相关性的新方向。本文是由Claus Heizmann、Joachim Krebs和Jacques Haiech编辑的题为：ECS会议的特刊的一部分。内溶酶体离子通道调节膜运输和自噬。TPC相互作用组集中在膜融合和病毒运输机制上。TPC 1相互作用组包括许多管腔阳离子稳态的调节剂。TRPML 1相互作用体由心脏和自噬相关蛋白组成。TRPML 3相互作用体由阳离子泵复合物和信号蛋白组成。
The endolysosomal, non-selective cation channels, two-pore channels (TPCs) and mucolipins (TRPMLs), regulate intracellular membrane dynamics and autophagy. While partially compensatory for each other, isoform-specific intracellular distribution, cell-type expression patterns, and regulatory mechanisms suggest different channel isoforms confer distinct properties to the cell. Briefly, established TPC/TRPML functions and interaction partners (‘interactomes’) are discussed. Novel TRPML3 interactors are shown, and a meta-analysis of experimentally obtained channel interactomes conducted. Accordingly, interactomes are compared and contrasted, and subsequently described in detail for TPC1, TPC2, TRPML1, and TRPML3. TPC interactomes are well-defined, encompassing intracellular membrane organisation proteins. TRPML interactomes are varied, encompassing cardiac contractility- and chaperone-mediated autophagy proteins, alongside regulators of intercellular signalling. Comprising recently proposed targets to treat cancers, infections, metabolic disease and neurodegeneration, the advancement of TPC/TRPML understanding is of considerable importance. This review proposes novel directions elucidating TPC/TRPML relevance in health and disease. This article is part of a Special Issue entitled: ECS Meeting edited by Claus Heizmann, Joachim Krebs and Jacques Haiech. Endolysosomal ion channels regulate membrane trafficking and autophagy. TPC interactomes converge upon the membrane fusion and viral trafficking machinery. TPC1 interactome includes numerous regulators of luminal cation homeostasis. TRPML1 interactome consists of cardiac and autophagy-related proteins. TRPML3 interactome consists of cation pump complexes and signalling proteins.
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DOI：
10.1074/jbc.m110.162073
发表时间：
2010-12-03
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Brailoiu E;Rahman T;Churamani D;Prole DL;Brailoiu GC;Hooper R;Taylor CW;Patel S
通讯作者：
Patel S
DOI：
10.1007/978-3-319-55858-5_14
发表时间：
2017-01-01
期刊：
MEMBRANE DYNAMICS AND CALCIUM SIGNALING
影响因子：
--
作者：
Enrich, Carlos;Rentero, Carles;Grewal, Thomas
通讯作者：
Grewal, Thomas
影响因子：
4.6
作者：
Aston D;Capel RA;Ford KL;Christian HC;Mirams GR;Rog-Zielinska EA;Kohl P;Galione A;Burton RA;Terrar DA
通讯作者：
Terrar DA
DOI：
10.1073/pnas.1705739114
发表时间：
2017-10-10
影响因子：
11.1
作者：
Chao, Yu-Kai;Schludi, Verena;Grimm, Christian
通讯作者：
Grimm, Christian
DOI：
10.1093/bioinformatics/btp101
发表时间：
2009-04-15
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Bindea G;Mlecnik B;Hackl H;Charoentong P;Tosolini M;Kirilovsky A;Fridman WH;Pagès F;Trajanoski Z;Galon J
通讯作者：
Galon J