Prevalence and risk factors for exposure to Toxoplasma gondii in slaughterhouse workers in western Kenya.
Prevalence and risk factors for exposure to Toxoplasma gondii in slaughterhouse workers in western Kenya.
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肯尼亚西部屠宰场工人中暴露于弓形虫弓形虫的患病率和危险因素。
DOI：
10.1186/s12879-021-06658-8
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发表时间：
2021-09-11
影响因子：
3.7
通讯作者：
Fèvre EM
中科院分区：
文献类型：
--
作者：
Cook EAJ;Gitahi N;de Glanville WA;Thomas LF;Kariuki S;Kang'ethe E;Fèvre EM
弓形虫是一种感染温血动物的人畜共患原虫。人类感染可通过以下途径发生：摄入终末宿主粪便中的卵囊;摄入受感染中间宿主组织中的缓殖子;或暴露于生奶和鸡蛋中的速殖子。屠宰场工人被认为是T。弓形虫暴露，因为他们接触生肉，虽然处理生肉和T。并不是所有研究都证实了弓形虫血清阳性。本研究的目的是确定T。在肯尼亚屠宰场工人的弓形虫，并确定与血清阳性相关的危险因素。在研究区域的142个屠宰场进行了屠宰场工人的调查。使用结构化问卷收集有关人口统计学、与牲畜接触、肉类消费和屠宰场做法的信息。用商品化的ELISA法检测T.弓形虫和多层次逻辑回归模型被用来确定屠宰场工人血清阳性的潜在危险因素。T.弓形虫IgG抗体阳性率为84.0%（95%可信区间（CI）81.2-86.5%），IgM抗体阳性率为2.2%（95% CI 1.3-3.5%）。所有IgM阳性者均为IgG阳性。暴露于T.弓形虫是：增加年龄（比值比（OR）1.03; 95%CI 1.01-1.05）;拥有家禽（OR 2.00; 95%CI 1.11-3.62）;和食用动物血（OR 1.92; 95%CI 1.21-3.03）。T.弓形虫在这一人群中非常高，远远高于一般人群中公布的值。风险因素包括年龄，拥有家禽和饮用动物血液，这些与以前的报告一致，但没有一个与屠宰场工作有关。在这种情况下，屠宰场工人可能是普通人群的一个有用的哨兵，因为接触水平也可能很高，可能对孕妇等弱势群体构成未知的公共卫生风险。需要对感染的流行病学有详细的了解，包括对T。感染弓形虫可能会有终身后遗症。
Toxoplasma gondii is a zoonotic protozoan parasite infecting warm-blooded animals. Infection in people can occur through ingestion of oocysts passed in the faeces of the definitive hosts; ingestion of bradyzoites in the tissue of infected intermediate hosts; or exposure to tachyzoites in raw milk and eggs. Slaughterhouse workers are considered a high-risk group for T. gondii exposure because of their contact with raw meat, although a positive relationship between handling raw meat and T. gondii seropositivity has not been demonstrated in all studies. This study aimed to determine the seroprevalence of antibodies to T. gondii in slaughterhouse workers in Kenya and identify risk factors associated with seropositivity. A survey of slaughterhouse workers was conducted in 142 slaughter facilities in the study area. Information regarding demographics, contact with livestock, meat consumption, and practices in the slaughterhouse was collected using structured questionnaires. Commercial ELISAs were used to detect IgM and IgG antibodies against T. gondii and a multi-level logistic regression model was used to identify potential risk factors for seropositivity in slaughterhouse workers. The apparent prevalence of antibodies to T. gondii was 84.0% (95% Confidence Interval (CI) 81.2–86.5%) for IgG and 2.2% (95% CI 1.3–3.5%) for IgM antibodies. All IgM positive individuals were IgG positive. Risk factors for exposure to T. gondii were: increasing age (Odds Ratio (OR) 1.03; 95% CI 1.01–1.05); owning poultry (OR 2.00; 95% CI 1.11–3.62); and consuming animal blood (OR 1.92; 95% CI 1.21–3.03). The seroprevalence of antibodies to T. gondii was very high in this population and considerably higher than published values in the general population. Risk factors included age, owning poultry and drinking animal blood which were consistent with previous reports but none were specifically associated with working in the slaughterhouse. In this instance slaughterhouse workers may represent a useful sentinel for the general population where the level of exposure is also likely to be high and may signify an unidentified public health risk to vulnerable groups such as pregnant women. A detailed understanding of the epidemiology of infection is required, which should include an assessment of incidence, mortality, and burden since T. gondii infection is likely to have life-long sequelae.
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影响因子：
3.2
作者：
Liu Q;Wang ZD;Huang SY;Zhu XQ
通讯作者：
Zhu XQ
DOI：
10.1017/s175173112000110x
发表时间：
2020-11
期刊：
Animal : an international journal of animal bioscience
影响因子：
--
作者：
Chaiban C;Robinson TP;Fèvre EM;Ogola J;Akoko J;Gilbert M;Vanwambeke SO
通讯作者：
Vanwambeke SO
影响因子：
3.8
作者：
Fujii Y;Kaneko S;Nzou SM;Mwau M;Njenga SM;Tanigawa C;Kimotho J;Mwangi AW;Kiche I;Matsumoto S;Niki M;Osada-Oka M;Ichinose Y;Inoue M;Itoh M;Tachibana H;Ishii K;Tsuboi T;Yoshida LM;Mondal D;Haque R;Hamano S;Changoma M;Hoshi T;Kamo K;Karama M;Miura M;Hirayama K
通讯作者：
Hirayama K
影响因子：
14.2
作者：
Hill, D;Dubey, JP
通讯作者：
Dubey, JP
DOI：
10.1016/0035-9203(86)90336-6
发表时间：
1986-01-01
影响因子：
2.2
作者：
BOWRY, TR;CAMARGO, ME;KINYANJUI, M
通讯作者：
KINYANJUI, M