Suppression of basophil histamine release and other IgE-dependent responses in childhood Schistosoma mansoni/hookworm coinfection.
Suppression of basophil histamine release and other IgE-dependent responses in childhood Schistosoma mansoni/hookworm coinfection.
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DOI：
10.1093/infdis/jiu234
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发表时间：
2014-10-15
期刊：
影响因子：
--
通讯作者：
Dunne DW
中科院分区：
文献类型：
--
作者：
Pinot de Moira A;Fitzsimmons CM;Jones FM;Wilson S;Cahen P;Tukahebwa E;Mpairwe H;Mwatha JK;Bethony JM;Skov PS;Kabatereine NB;Dunne DW
背景：在蠕虫感染人群中，过敏原特异性免疫球蛋白E（asIgE）与变态反应的临床症状之间的相关性较差，这表明蠕虫感染可以通过将asIgE与其效应机制解偶联来对抗变态反应。 我们调查了这一假设，在乌干达的学龄儿童合并感染曼氏血吸虫和钩虫。方法：在驱虫治疗前评估皮肤点刺试验（SPT）对屋尘螨过敏原（HDM）的敏感性和当前喘息。 治疗前和治疗后测量非特异性（抗IgE）、蠕虫特异性和HDM-过敏原特异性嗜碱性粒细胞组胺释放（HR），以及蠕虫和HDM-特异性IgE和IgG 4应答。结果：治疗后非特异性和蠕虫特异性HR，以及蠕虫特异性IgE和蠕虫特异性HR之间的相关性增加。 钩虫感染似乎改变了HDM-IgE和HR的循环水平之间的关系：在没有检测到钩虫感染的儿童中观察到显着的正相关性，但在感染儿童中没有观察到相关性。此外，钩虫感染与哮鸣风险显著降低相关，体细胞成虫钩虫抗原IgG 4与HDM-SPT敏感性风险降低相关。没有证据表明S。曼氏感染对HDM-HR或过敏症状具有类似的抑制作用。结论：嗜碱性粒细胞的反应性在慢性蠕虫感染中受到抑制;至少在钩虫感染中，这种抑制可以保护机体免受过敏。
Background. The poor correlation between allergen-specific immunoglobulin E (asIgE) and clinical signs of allergy in helminth infected populations suggests that helminth infections could protect against allergy by uncoupling asIgE from its effector mechanisms. We investigated this hypothesis in Ugandan schoolchildren coinfected with Schistosoma mansoni and hookworm. Methods. Skin prick test (SPT) sensitivity to house dust mite allergen (HDM) and current wheeze were assessed pre-anthelmintic treatment. Nonspecific (anti-IgE), helminth-specific, and HDM-allergen-specific basophil histamine release (HR), plus helminth- and HDM-specific IgE and IgG4 responses were measured pre- and post-treatment. Results. Nonspecific- and helminth-specific-HR, and associations between helminth-specific IgE and helminth-specific HR increased post-treatment. Hookworm infection appeared to modify the relationship between circulating levels of HDM-IgE and HR: a significant positive association was observed among children without detectable hookworm infection, but no association was observed among infected children. In addition, hookworm infection was associated with a significantly reduced risk of wheeze, and IgG4 to somatic adult hookworm antigen with a reduced risk of HDM-SPT sensitivity. There was no evidence for S. mansoni infection having a similar suppressive effect on HDM-HR or symptoms of allergy. Conclusions. Basophil responsiveness appears suppressed during chronic helminth infection; at least in hookworm infection, this suppression may protect against allergy.
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影响因子：
4.8
作者：
Bethony, J;Loukas, A;Hotez, PJ
通讯作者：
Hotez, PJ
影响因子：
14.2
作者：
Kepley, CL;Cambier, JC;Oliver, JM
通讯作者：
Oliver, JM
影响因子：
4.4
作者：
Cady, Carol T.;Powell, Maree S.;Cambier, John C.
通讯作者：
Cambier, John C.
影响因子：
4.6
作者：
Geiger, SM;Massara, CL;Corrêa-Oliveira, R
通讯作者：
Corrêa-Oliveira, R
影响因子：
168.9
作者：
Beasley, R;Keil, U;Williams, HC
通讯作者：
Williams, HC