Intracellular escape strategies of Staphylococcus aureus in persistent cutaneous infections.
Intracellular escape strategies of Staphylococcus aureus in persistent cutaneous infections.
复制标题
DOI：
10.1111/exd.14235
复制
发表时间：
2021-10
影响因子：
3.6
通讯作者：
Igoucheva O
中科院分区：
文献类型：
--
作者：
Huitema L;Phillips T;Alexeev V;Tomic-Canic M;Pastar I;Igoucheva O
金黄色葡萄球菌的病原性侵袭是患有慢性皮肤病（如特应性皮炎（AD）、大疱性表皮炎（EB）或慢性糖尿病足和静脉性腿部溃疡）的患者的主要问题，并且可导致持续性和危及生命的慢性不愈合伤口。金黄色葡萄球菌通常被认为是细胞外病原体。然而，S.金黄色葡萄球菌还可以侵入、隐藏和存留在皮肤细胞中，从而导致伤口慢性化。S.金黄色葡萄球菌是目前不完全了解，虽然已发表的研究表明，其细胞内逃逸策略在持续性皮肤感染中发挥重要作用。本文综述了近年来关于S.金黄色葡萄球菌在皮肤细胞，其中可分为专业和非专业的抗原呈递细胞，及其策略，以逃避适应性防御机制。首先，我们讨论了S.金黄色葡萄球菌，其影响细胞内路由和降解。本文还对S.金黄色葡萄球菌，以避免细胞内降解和抗原呈递，防止免疫应答。此外，我们讨论了潜在的药物靶点，可以干扰细胞内的生命周期的S。金黄色。本文旨在加深对S.金黄色葡萄球菌进入皮肤细胞及其逃避宿主免疫反应的策略，这些信息对于减少致病性入侵和危及生命的持续存在至关重要。金黄色葡萄球菌在慢性皮肤感染。
Pathogenic invasion of Staphylococcus aureus is a major concern in patients with chronic skin diseases like atopic dermatitis (AD), epidermolysis bullosa (EB), or chronic diabetic foot and venous leg ulcers, and can result in persistent and life-threatening chronic non-healing wounds. Staphylococcus aureus is generally recognized as extracellular pathogens. However, S. aureus can also invade, hide and persist in skin cells to contribute to wound chronicity. The intracellular life cycle of S. aureus is currently incompletely understood, although published studies indicate that its intracellular escape strategies play an important role in persistent cutaneous infections. This review provides current scientific knowledge about the intracellular life cycle of S. aureus in skin cells, which can be classified into professional and non-professional antigen-presenting cells, and its strategies to escape adaptive defense mechanisms. First, we discuss phenotypic switch of S. aureus, which affects intracellular routing and degradation. This review also evaluates potential intracellular escape mechanism of S. aureus to avoid intracellular degradation and antigen presentation, preventing an immune response. Furthermore, we discuss potential drug targets that can interfere with the intracellular life cycle of S. aureus. Taken together, this review aimed to increase scientific understanding about the intracellular life cycle of S. aureus into skin cells and its strategies to evade the host immune response, information that is crucial to reduce pathogenic invasion and life-threatening persistence of S. aureus in chronic cutaneous infections.
登录
查看更多内容
影响因子：
5.2
作者：
Asadollahi P;Farahani NN;Mirzaii M;Khoramrooz SS;van Belkum A;Asadollahi K;Dadashi M;Darban-Sarokhalil D
通讯作者：
Darban-Sarokhalil D
影响因子：
4
作者：
Abers, Harald M. H. G.;Kuijl, Coenraad;Neefjes, Jacques
通讯作者：
Neefjes, Jacques
临床前模型和方法，用于使用非侵入性光学成像监测金黄色葡萄球菌感染。
DOI：
10.1007/978-1-4939-9849-4_15
发表时间：
2020
期刊：
Methods in molecular biology (Clifton, N.J.)
影响因子：
--
作者：
Archer NK;Wang Y;Ortines RV;Liu H;Nolan SJ;Liu Q;Alphonse MP;Dikeman DA;Mazhar M;Miller RJ;Anderson LS;Francis KP;Simon SI;Miller LS
通讯作者：
Miller LS
影响因子：
3.4
作者：
Jubrail J;Morris P;Bewley MA;Stoneham S;Johnston SA;Foster SJ;Peden AA;Read RC;Marriott HM;Dockrell DH
通讯作者：
Dockrell DH
影响因子：
6.4
作者：
Grundmeier, Matthias;Tuchscherr, Lorena;Loeffler, Bettina
通讯作者：
Loeffler, Bettina