Positron emission tomography (PET) for prediction of glioma histology: protocol for an individual-level data meta-analysis of test performance.
Positron emission tomography (PET) for prediction of glioma histology: protocol for an individual-level data meta-analysis of test performance.
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DOI：
10.1136/bmjopen-2017-020187
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发表时间：
2018-02-17
期刊：
影响因子：
2.9
通讯作者：
Terasawa T
中科院分区：
文献类型：
--
作者：
Trikalinos NA;Nihashi T;Evangelou E;Terasawa T
神经胶质瘤是最常诊断的原发性脑肿瘤，部分基于其组织学亚型，与不同的存活率相关。因此，准确的治疗前肿瘤分级对于患者护理和临床试验设计至关重要。我们将对已发表的研究进行个体水平的数据荟萃分析，以评估不同类型的正电子发射断层扫描（PET）区分高级别和低级别胶质瘤的能力。我们将检索PubMed和Scopus，从开始到2017年7月30日，无语言限制，并对潜在相关文章进行全文评价。我们将选择使用18-氟脱氧葡萄糖（18 F-FDG）、l-[甲基-（）11 C]甲硫氨酸（11 C-MET）、18 F-Fluoro-Ethyl-Tyrosine（18 F-FET）或（18）F-Fluorothymidine（18 F-FLT）评估PET的研究进行分级，并通过组织学确认进行验证。我们将包括前瞻性和回顾性研究。偏倚将由两名审查员使用诊断准确性研究质量评估-2工具并按照Deeks等人描述的方法进行评估。伦理批准不适用，因为这是一项荟萃分析研究。分析结果将提交同行评审期刊发表。CRD42017078649。
Gliomas, the most commonly diagnosed primary brain tumours, are associated with varied survivals based, in part, on their histological subtype. Therefore, accurate pretreatment tumour grading is essential for patient care and clinical trial design. We will perform an individual-level data meta-analysis of published studies to evaluate the ability of different types of positron emission tomography (PET) to differentiate high from low-grade gliomas. We will search PubMed and Scopus from inception through 30 July 2017 with no language restriction and full-text evaluation of potentially relevant articles. We will choose studies that assess PET using 18-Fludeoxyglucose (18F-FDG), l-[Methyl-()11C]Methionine (11C-MET), 18F-Fluoro-Ethyl-Tyrosine (18F-FET) or (18)F-Fluorothymidine (18F-FLT)for grading, verified with histological confirmation. We will include both prospective and retrospective studies. Bias will be assessed by two reviewers with the Quality Assessment of Diagnostic Accuracy Studies-2 tool and as per method described by Deeks et al. Ethics approval was not applicable, as this is a meta-analytic study. Results of the analysis will be submitted for publication in a peer-reviewed journal. CRD42017078649.
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影响因子：
2
作者：
Riley, Richard D.;Dodd, Susanna R.;Williamson, Paula R.
通讯作者：
Williamson, Paula R.
影响因子：
7.2
作者：
Deeks, JJ;Macaskill, P;Irwig, L
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Irwig, L
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15.9
作者：
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6.4
作者：
Thon, Niklas;Kunz, Mathias;Kreth, Friedrich-Wilhelm
通讯作者：
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