Amygdala response to negative stimuli predicts PTSD symptom onset following a terrorist attack.
Amygdala response to negative stimuli predicts PTSD symptom onset following a terrorist attack.
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DOI：
10.1002/da.22284
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发表时间：
2014-10
影响因子：
7.4
通讯作者：
Sheridan, Margaret A.
中科院分区：
文献类型：
--
作者：
McLaughlin, Katie A.;Busso, Daniel S.;Duys, Andrea;Green, Jennifer Greif;Alves, Sonia;Way, Marcus;Sheridan, Margaret A.
患有创伤后应激障碍（PTSD）的个体在对负面情绪信息做出反应时表现出杏仁核反应性增强和内侧前额叶皮层（mPFC）的非典型激活模式。目前尚不清楚这些神经功能方面是否是PTSD的危险因素，或者是创伤暴露或疾病发作的后果。在2013年波士顿马拉松恐怖袭击以及随后的搜捕和庇护所秩序之后，我们有一个独特的机会来调查这个问题。我们研究了与这些事件相关的PTSD症状发作的攻击前测量的神经功能的关联。一个样本的15名青少年（平均年龄=16.5岁）谁以前参加了神经影像学研究完成了一项调查，评估创伤后症状与恐怖袭击。我们研究了血氧水平依赖性（BOLD）反应，以查看和积极下调情绪反应的负性刺激，在以前与创伤后应激障碍，包括杏仁核，海马，和mPFC，作为创伤后症状发作的前瞻性预测因子。左杏仁核中对负面情绪刺激的BOLD信号增加与袭击后的创伤后症状密切相关。在努力尝试下调对负面刺激的情绪反应时，双侧海马激活减少也与更严重的创伤后症状有关。杏仁核反应性与创伤后症状之间的关联，与先前存在的抑郁、焦虑、创伤后应激障碍症状和先前暴露于暴力的对照组相比，是稳健的。杏仁核对负面情绪信息的反应可能代表了创伤应激脆弱性的神经生物学标志，并且可能是PTSD的风险因素。
Individuals with post-traumatic stress disorder (PTSD) exhibit heightened amygdala reactivity and atypical activation patterns in the medial prefrontal cortex (mPFC) in response to negative emotional information. It is unknown whether these aspects of neural function are risk factors for PTSD or consequences of either trauma exposure or onset of the disorder. We had a unique opportunity to investigate this issue following the terrorist attacks at the 2013 Boston Marathon and the ensuing manhunt and shelter in place order. We examined associations of neural function measured prior to the attack with PTSD symptom onset related to these events. A sample of 15 adolescents (mean age=16.5 years) who previously participated in a neuroimaging study completed a survey assessing posttraumatic symptoms related to the terrorist attack. We examined blood oxygen-level dependent (BOLD) response to viewing and actively down-regulating emotional responses to negative stimuli in regions previously associated with PTSD, including the amygdala, hippocampus, and mPFC, as prospective predictors of posttraumatic symptom onset. Increased BOLD signal to negative emotional stimuli in the left amygdala was strongly associated with posttraumatic symptoms following the attack. Reduced bilateral hippocampal activation during effortful attempts to down-regulate emotional responses to negative stimuli was also associated with greater posttraumatic symptoms. Associations of amygdala reactivity with posttraumatic symptoms were robust to controls for pre-existing depression, anxiety, and PTSD symptoms and prior exposure to violence. Amygdala reactivity to negative emotional information might represent a neurobiological marker of vulnerability to traumatic stress and, potentially, a risk factor for PTSD.
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影响因子：
3.5
作者：
Gorgolewski K;Burns CD;Madison C;Clark D;Halchenko YO;Waskom ML;Ghosh SS
通讯作者：
Ghosh SS
DOI：
10.1097/00004583-199703000-00012
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1997-03-01
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作者：
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通讯作者：
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DOI：
10.1093/jurban/jth138
发表时间：
2004-12-01
影响因子：
6.6
作者：
Breslau, N;Wilcox, HC;Anthony, JC
通讯作者：
Anthony, JC