Nontoxic nerve guide tubes support neovascular growth in transected rat optic nerve
Nontoxic nerve guide tubes support neovascular growth in transected rat optic nerve
复制标题
无毒神经导管支持横断大鼠视神经的新生血管生长
DOI：
10.1016/0014-4886(84)90080-3
复制
发表时间：
1984
影响因子：
5.3
通讯作者：
D. Greatorex
中科院分区：
文献类型：
--
作者：
R. Madison;R. Sidman;E. Nyilas;T. Chiu;D. Greatorex
Nontoxic, bioresorbable “nerve guide” tubes were used to bridge the transected optic nerves of adult rats. Nerve guides were fabricated as polymers of synthetic polyd,l-lactates with 2% triethyl citrate added as a plasticizer. The local environment was manipulated further by the addition of the proteins collagen, fibrinogen, and anti-Thy-1 antibody to the nerve guide lumens at the time of operation. Neovascular growth through the nerve guide lumens was quantified with the aid of a computer-controlled microscope. Neovascular growth was greater in the nerve guides to which proteins had been added, compared with initially empty nerve guides. These experiments demonstrated the effectiveness of these nerve guide tubes in supporting and directing neovascular growth in the mammalian central nervous system, and suggested that specific alterations of the local environment within the nerve guide lumen can affect the extent of neovascular growth.
影响因子：
56.9
作者：
LEE, A;LANGER, R
通讯作者：
LANGER, R
影响因子：
56.9
作者：
FOLKMAN, J;LANGER, R;TAYLOR, S
通讯作者：
TAYLOR, S